Nova Fong
University of Colorado Denver
29 Papers
11 Citations
Nova Fong is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: RNA polymerase II & Transcription (biology). The author has an hindex of 18, co-authored 22 publications. Previous affiliations of Nova Fong include Amgen & University of Colorado Hospital.
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Papers
The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.
Susan McCracken,Nova Fong,Krassimir Yankulov,Scott Ballantyne,Guohua Pan,Jack Greenblatt,Scott D. Patterson,Marvin Wickens,David Bentley +8 more
TL;DR: It is shown that the carboxy-terminal domain of the pol II large subunit is required for efficient RNA processing, and an association between the CTD and 3′-processing factors suggests that an mRNA 'factory' exists which carries out coupled transcription, splicing and cleavage–polyadenylation of mRNA precursors.
974
5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II
Susan McCracken,Nova Fong,Emanuel Rosonina,Krassimir Yankulov,David P. Siderovski,Andrew Hessel,Foster Stephen,Amgen Est Program,Stewart Shuman,David Bentley +9 more
TL;DR: Results suggest that Pol II-specific capping of nascent transcripts in vivo is enhanced by recruitment of the capping enzymes to the CTD and capping is co-ordinated with CTD phosphorylation.
Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate
Nova Fong,Hyunmin Kim,Yu Zhou,Xiong Ji,Jinsong Qiu,Tassa K Saldi,Katrina Diener,Kenneth L. Jones,Xiang-Dong Fu,David Bentley +9 more
TL;DR: It is suggested that an optimal rate of transcriptional elongation is required for normal cotranscriptional pre-mRNA splicing.
307
Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition
Nova Fong,Kristopher W. Brannan,Benjamin Erickson,Hyunmin Kim,Michael A. Cortazar,Ryan M. Sheridan,Tram Nguyen,Shai Karp,David Bentley +8 more
TL;DR: Using pol II rate mutants, it is found that slow transcription robustly shifts termination upstream, and fast elongation extends the zone of termination further downstream, suggesting that kinetic competition between elongating pol II and the Xrn2 exonuclease is integral to termination of transcription on most human genes.
225
Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism.
Michael A. Cortazar,Ryan M. Sheridan,Benjamin Erickson,Nova Fong,Kira Glover-Cutter,Kristopher W. Brannan,David Bentley +6 more
TL;DR: A model for termination, the "sitting duck torpedo" mechanism, where poly(A) site-dependent deceleration caused by PNUTS-PP1 and Spt5 dephosphorylation is required to convert Pol II into a viable target for the Xrn2 terminator exonuclease.
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