You have thrown many brightly colored patches into the sewing box. Usually the tailor sews them into a crazy quilt; I will try to sew the patches into a Joseph’s coat. Since they were thrown into the box without regard for the tailor’s skill, some of them will be left over. This will be the way of deciding whether the coat is well made, for it must be judged by the patches which are used as well as by those which are not.

The take-home lesson--1971.

The control of humoral and associative antibody synthesis.

We propose to evaluate the comjx'ting theories of induction and paralysis. Our analysis has been evoked by Coutinho & M611er\"s perceptive discussion of this question (15). Tlie first step in the C'outinho Moller analysis consisted of reducing all formulations of the self-nonself discrimination to two competing theories that they term the oneand /«YJ-signal models of induction and paralysis. Their second step was to provide us with a precisely stated one-signal model. Thus they gave us a framework within which to discuss the 'self-nonself discrimination' problem in a way that should not permit misinterpretation of the argument. The progression of our argument will be opposite to that of Coutinho & Moller. Their onesignal model is derived essentially from an attempt to understand polyclonal induction (Section Vni), which of course is explained with admirable simplicity. However, the}' ignore what we know about the way in which the decision between induction and paralysis is made by the normal immune system. It is this key distinction that the one-signal model cannot account for and which led to the postulation of the two-signal model. We, therefore, will open by developing the reasoning that leads to oneand two-signal models before showing why all one-signal motitis are untenable. We will close by arguing that the available data on polyclonai induction can be explained in many ways compatible with a two-signal model and for this reason present no challenge to it.

The Self‐Nonself Discrimination: A One‐ or Two‐Signal Mechanism?

Increase and decrease in binding affinity of antibodies during the immune response

Immunology: What are the rules of the game?

The cellular basis of immunity.

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The cellular basis of immunity.