Norbert Schormann
University of Alabama at Birmingham
32 Papers
248 Citations
Norbert Schormann is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Uracil-DNA glycosylase & DNA glycosylase. The author has an hindex of 12, co-authored 30 publications. Previous affiliations of Norbert Schormann include University of Alabama.
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Papers
Uracil‐DNA glycosylases—Structural and functional perspectives on an essential family of DNA repair enzymes
TL;DR: The structural basis for substrate specificity and base recognition as well as for DNA binding, nucleotide flipping and catalytic mechanism is discussed in detail and the latest studies and findings detailing structure and function are presented.
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An Overview of Structure, Function and Regulation of Pyruvate Kinases
TL;DR: Results of recent studies on pyruvate kinases of different families suggest that members of evolutionarily related families follow somewhat conserved allosteric strategies but evolutionarily distant members adopt different strategies.
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Structure‐based approach to pharmacophore identification, in silico screening, and three‐dimensional quantitative structure–activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function
Norbert Schormann,Olga Senkovich,Kiera Walker,Dennis L. Wright,Amy C. Anderson,Andre Rosowsky,Subramaniam Ananthan,Bidhan A. Shinkre,Sadanandan E. Velu,Debasish Chattopadhyay +9 more
TL;DR: A structure‐based three‐dimensional quantitative structure–activity relationship (3D‐QSAR) approach to predict the biochemical activity for inhibitors of T. cruzi dihydrofolate reductase‐thymidylate synthase and human DHFR to generate a library of selective lead inhibitors for further development as antiparasitic agents.
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Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly.
Norbert Schormann,Alexei Grigorian,Alexandra B. Samal,Raman Krishnan,Lawrence J. DeLucas,Debasish Chattopadhyay +5 more
TL;DR: The crystal structures reveal several distinctive features of vvUDG that may have evolved for adopting novel functions in the replication machinery of poxviruses and suggests a possible model for binding to its partner and the nature of the processivity factor in the polymerase complex.
Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase.
Norbert Schormann,Sadanandan E. Velu,Srinivasan Murugesan,Olga Senkovich,Kiera Walker,Balachandra Chenna,Bidhan A. Shinkre,Amar Desai,Debasish Chattopadhyay +8 more
TL;DR: Synthesis and characterization of six potent inhibitors of the parasitic enzyme dihydrofolate reductase-thymidylate synthase enzyme of Trypanosoma cruzi are reported here.
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