Norbert Kinkl

TL;DR: Data indicate that FGF2-induced ERK1/2 activation is entirely mediated by MEK within photoreceptors, which is responsible for FGF 2-stimulated photoreceptor survival, and inner retina/glia possess alternative, cell type, and growth factor-specific MEK-independent ERK 1/2activation pathways.

TL;DR: Screening of different neural and nonneural tissues by reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that whereas FGFR1 and R2 were strongly expressed in adult cortex, cerebellum, retina, and kidney, robust FGFR4 expression was only seen in retina and kidney; potential roles of these signal transduction molecules in FGF-induced biological responses in the retina are discussed.

TL;DR: The adult pig photoreceptor culture in the current study exhibits reproducible neuronal survival in vitro and represents a useful novel experimental system for the study of potential neuroprotective effects and signaling pathways of neurotrophic factors such as FGF2 and EGF in fully adult higher mammalian retina.

TL;DR: Rat and human retinal cells showed a largely similar, widespread expression of multiple FGFR and candidate FGFR-related signaling molecules, suggesting that specific FGFR/FGF ligands and transduction pathways may operate in different cells.