Nora C. Toussaint
ETH Zurich
53 Papers
49 Citations
Nora C. Toussaint is an academic researcher from ETH Zurich. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 24, co-authored 47 publications. Previous affiliations of Nora C. Toussaint include University of Zurich & Kettering University.
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Papers
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.
Charlie G. Buffie,Vanni Bucci,Vanni Bucci,Richard R. Stein,Peter T. McKenney,Lilan Ling,Asia Gobourne,Daniel No,Hui Liu,Melissa A. Kinnebrew,Agnes Viale,Eric R. Littmann,Marcel R.M. van den Brink,Marcel R.M. van den Brink,Robert R. Jenq,Ying Taur,Chris Sander,Justin R. Cross,Nora C. Toussaint,Nora C. Toussaint,Joao B. Xavier,Joao B. Xavier,Eric G. Pamer,Eric G. Pamer +23 more
TL;DR: It is determined that Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium, is associated with resistance to C. difficile infection and, upon administration, enhances resistance to infection in a secondary bile Acid dependent fashion.
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Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.
André Kahles,Kjong-Van Lehmann,Nora C. Toussaint,Matthias Hüser,Stefan G. Stark,Timo Sachsenberg,Oliver Stegle,Oliver Kohlbacher,Chris Sander,Gunnar Rätsch +9 more
TL;DR: The authors' comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas cancer types from 8,705 patients detectsAlternative splicing events and tumor variants by reanalyzing RNA and whole-exome sequencing data.
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Ecological modeling from time-series inference: insight into dynamics and stability of intestinal microbiota.
Richard R. Stein,Vanni Bucci,Nora C. Toussaint,Charlie G. Buffie,Gunnar Rätsch,Eric G. Pamer,Chris Sander,Joao B. Xavier +7 more
TL;DR: A novel method to infer microbial community ecology directly from time-resolved metagenomics is presented, extending generalized Lotka–Volterra dynamics to account for external perturbations and suggests a subnetwork of bacterial groups implicated in protection against C. difficile.
Intestinal Microbiota Containing Barnesiella Species Cures Vancomycin-Resistant Enterococcus faecium Colonization
Carles Ubeda,Carles Ubeda,Vanni Bucci,Silvia Caballero,Silvia Caballero,Ana Djukovic,Nora C. Toussaint,Nora C. Toussaint,Michele Equinda,Michele Equinda,Lauren Lipuma,Lauren Lipuma,Lilan Ling,Lilan Ling,Asia Gobourne,Asia Gobourne,Daniel No,Daniel No,Ying Taur,Robert R. Jenq,Marcel R.M. van den Brink,Joao B. Xavier,Eric G. Pamer,Eric G. Pamer +23 more
TL;DR: It is demonstrated that reintroduction of a diverse intestinal microbiota to densely VRE-colonized mice eliminates VRE from the intestinal tract and indicates that obligate anaerobic bacteria belonging to the Barnesiella genus enable clearance of intestinal VRE colonization and may provide novel approaches to prevent the spread of highly antibiotic-resistant bacteria.
Proton Pump Inhibitors Alter Specific Taxa in the Human Gastrointestinal Microbiome: A Crossover Trial
Daniel E. Freedberg,Nora C. Toussaint,Sway P. Chen,Adam J. Ratner,Susan Whittier,Timothy C. Wang,Harris H. Wang,Julian A. Abrams +7 more
TL;DR: In a functional analysis, there were no changes in bile acids on PPIs, but there was an increase in genes involved in bacterial invasion that could provide a mechanism by which PPIs predispose to CDI.
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