Nobuyoshi Shimizu
Keio University
504 Papers
6.6K Citations
Nobuyoshi Shimizu is an academic researcher from Keio University. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 84, co-authored 504 publications. Previous affiliations of Nobuyoshi Shimizu include Juntendo University & Nagahama Institute of Bio-Science and Technology.
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Papers
Detection of epidermal growth factor receptor gene amplification in human squamous cell carcinomas using fluorescence in situ hybridization
TL;DR: This study employed the improved fluorescence in situ hybridization technique to detect EGFR gene amplification in cell lines and tissue sections from human squamous cell carcinomas and detected multiple distinct signals as arrayed amplicons on metaphase chromosomes and interphase nuclei of tumor cells.
Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.
TL;DR: It is postulated that the SGSM family members function as modulators of the small G protein RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways.
Two patients with atypical interstitial deletions of 8p23.1: mapping of phenotypical traits.
Marco T. Páez,Toshiyuki Yamamoto,Ken-ichi Hayashi,Toshiyuki Yasuda,Naoki Harada,Naomichi Matsumoto,Kenji Kurosawa,Yoshiyuki Furutani,Shuichi Asakawa,Nobuyoshi Shimizu,Rumiko Matsuoka +10 more
TL;DR: The critical regions and genes for clinical manifestation of 8p23 deletion syndrome, including facial anomalies, microcephaly, behavioral abnormality, and developmental delay, were discussed.
High frequency of mutations at position 11778 in mitochondrial nd4 gene in japanese families with leber's hereditary optic neuropathy
TL;DR: The prevalence of a point mutation at position 11778 in the ND4 gene of mitochondrial DNA appears to be much higher in Japanese patients with LHON than in patients of other ethnic origins, such as Finnish, Dutch, German, and English families.
WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development.
Norimasa Iwanami,Tomokazu Higuchi,Yumi Sasano,Toshinobu Fujiwara,Vu Q. Hoa,Minoru Okada,Sadiqur R. Talukder,Sanae Kunimatsu,Jie Li,Fumi Saito,Chitralekha Bhattacharya,Angabin Matin,Takashi Sasaki,Nobuyoshi Shimizu,Hiroshi Mitani,Heinz Himmelbauer,Akihiro Momoi,Hisato Kondoh,Makoto Furutani-Seiki,Yousuke Takahama +19 more
TL;DR: It is found that WDR55 is a novel nucleolar protein involved in the production of ribosomal RNA (rRNA) and is a nuclear modulator of rRNA synthesis, cell cycle progression, and embryonic organogenesis including teleost thymus development.