Nobuyoshi Shimizu
Keio University
504 Papers
6.6K Citations
Nobuyoshi Shimizu is an academic researcher from Keio University. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 84, co-authored 504 publications. Previous affiliations of Nobuyoshi Shimizu include Juntendo University & Nagahama Institute of Bio-Science and Technology.
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Papers
A Method for Evaluating Phylogenetic Relationship of α-Satellite DNA Suprachromosomal Family by Nucleotide Frequency Calculation
TL;DR: The sequence similarity among chromosome-specific alpha-satellite DNA was quantitatively evaluated by a novel procedure: nucleotide frequency calculation, indicating that the nucleotidefrequency calculation worked effectively to estimate the distances between satellite arrays.
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Unique chromosomal location of amplified EGF receptor genes in EGF receptor-hyperproducing tumor cell line NA.
TL;DR: The epidermal growth factor receptor (EGFR) gene was analyzed using a squamous cell carcinoma line NA, which has high numbers of EGF receptors and carries a 20-fold amplification of EGFR genes, which provides new evidence in regard to the location of the amplified EGFR gene in tumor cells.
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Genomic Organization and Complete Nucleotide Sequence of the TMEM1 Gene on Human Chromosome 21q22.3
Kentaro Nagamine,Kentaro Nagamine,Jun Kudoh,Kazuhiko Kawasaki,Shinsei Minoshima,Shuichi Asakawa,Fumiaki Ito,Nobuyoshi Shimizu +7 more
TL;DR: It is determined that the TMEM1 gene encodes a protein of 1,259 amino acids, which is 69-amino acids longer than the previously reported sequence.
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Mapping of the human gene for a melanocyte protein Pmel 17 (D12S53E) to chromosome 12q13-q14.
Ryo Kubota,Yimin Wang,Shinsei Minoshima,Jun Kudoh,Yukihiko Mashima,Yoshihisa Oguchi,Nobuyoshi Shimizu +6 more
TL;DR: Evidence precisely locating the human Pmel 17 gene to chromosome 12q13-q14 is presented, showing that the protein expressed in Escherichia coli cross-reacts with anti-tyrosinase antibodies.
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Reduced tyrosine phosphorylation and non-responsiveness to EGF-mediated cytotoxicity in EGF receptor-hyperproducing UCVA-1 cells
TL;DR: Non-responsiveness of UCVA-1 cells to EGF is correlated with the reduced tyrosine phosphorylation, indicating that the EGF receptor kinase is active and subject to autophosphorylation.
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