Nobuo Imai
Chugai Pharmaceutical Co.
18 Papers
233 Citations
Nobuo Imai is an academic researcher from Chugai Pharmaceutical Co.. The author has contributed to research in topics: Erythropoietin & In vivo. The author has an hindex of 12, co-authored 18 publications.
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Papers
Severe hyperparathyroidism with bone abnormalities and metastatic calcification in rats with adenine-induced uraemia
Keiichi Tamagaki,Qunsheng Yuan,Hiroyuki Ohkawa,Ikuo Imazeki,Yoshiyuki Moriguchi,Nobuo Imai,Susumu Sasaki,Kazuo Takeda,Masafumi Fukagawa +8 more
TL;DR: Uraemic rats made by adenine diet developed severe abnormalities of calcium metabolism in a relatively short period and therefore they may serve as a useful model for the analysis of parathyroid hyperplasia and vascular calcification in chronic renal failure.
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Effect of recombinant human erythropoietin on anticancer drug-induced anaemia.
Tomoko Matsumoto,Kouichi Endoh,Keiichi Kamisango,Kenichi Akamatsu,Kinya Koizumi,Masato Higuchi,Nobuo Imai,Hiroki Mitsui,Tsutomu Kawaguchi +8 more
TL;DR: The therapeutic effects of recombinant human erythropoietin (rHu Epo) on these anticancer drug‐induced anaemias were investigated.
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NG-monomethyl-l-arginine inhibits erythropoietin gene expression by stimulating GATA-2
Takahisa Tarumoto,Shigehiko Imagawa,Ken Ohmine,Tadashi Nagai,Masato Higuchi,Nobuo Imai,Norio Suzuki,Masayuki Yamamoto,Keiya Ozawa +8 more
TL;DR: The hypothesis that L-NMMA is one of the candidate substances that underlie the pathogenesis of renal anemia is supported and is demonstrated to have no effect on the binding activity of hepatic nuclear factor-4, COUP-TF1, hypoxia-inducing factor-1, or NF-κB.
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Thrombopoietic activity of human interleukin-6.
Toshiro Nagasawa,Tetsuro Orita,Jun-Ichi Matsushita,Masayuki Tsuchiya,Tomohiro Neichi,Ikuo Imazeki,Nobuo Imai,Norimichi Ochi,Hiroshi Kanma,Tsukasa Abe +9 more
TL;DR: It is concluded that commercial recombinant human IL‐6 produced in Escherichia coli, stimulated megakaryocyte colony formation in the presence of mouse interleukin‐3 and increased the number of peripheral platelets in mice in a dose‐dependent manner.
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In vivo effect of recombinant human leukemia inhibitory factor in primates
Yasuto Akiyama,Naoko Kajimura,Junichi Matsuzaki,Yasufumi Kikuchi,Nobuo Imai,Manabu Tanigawa,Ken Yamaguchi +6 more
TL;DR: It is demonstrated that rhLIF induces weight loss and thrombocytosis in a primate model and these biological effects disappeared soon after the cessation ofrhLIF treatment.
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