Nobuhiro Yamada
University of Tsukuba
402 Papers
4.8K Citations
Nobuhiro Yamada is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Diabetes mellitus & Cholesterol. The author has an hindex of 82, co-authored 402 publications. Previous affiliations of Nobuhiro Yamada include University of Tokyo & Kyoto University.
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Papers
Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women: A Meta-analysis
Satoru Kodama,Kazumi Saito,Shiro Tanaka,Miho Maki,Yoko Yachi,Mihoko Asumi,Ayumi Sugawara,Kumiko Totsuka,Hitoshi Shimano,Yasuo Ohashi,Nobuhiro Yamada,Hirohito Sone +11 more
TL;DR: In this article, a systematic literature search was conducted for observational cohort studies using MEDLINE (1966 to December 31, 2008) and EMBASE (1980 to December 30, 2008), which reported associations of baseline cardiorespiratory fitness with CHD events, CVD events, or all-cause mortality in healthy participants.
2.9K
Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis
Satoru Kodama,Shiro Tanaka,Kazumi Saito,Miao Shu,Yasuko Sone,Fumiko Onitake,Emiko Suzuki,Hitoshi Shimano,Shigeru Yamamoto,Kazuo Kondo,Yasuo Ohashi,Nobuhiro Yamada,Hirohito Sone +12 more
TL;DR: There appears to exist a minimum exercise volume for a significant increase in HDL-C level, and exercise duration per session was the most important element of an exercise prescription.
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Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
Tomohiro Yoshikawa,Hitoshi Shimano,Michiyo Amemiya-Kudo,Naoya Yahagi,Alyssa H. Hasty,Takashi Matsuzaka,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Jun-ichi Osuga,Kenji Harada,Takanari Gotoda,Satoshi Kimura,Shun Ishibashi,Nobuhiro Yamada +15 more
TL;DR: It is demonstrated that LXR-RXR can modify the expression of genes for lipogenic enzymes by regulating SREBP-1c expression, providing a novel link between fatty acid and cholesterol metabolism.
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
Takashi Matsuzaka,Hitoshi Shimano,Naoya Yahagi,Naoya Yahagi,Toyonori Kato,Ayaka Atsumi,Takashi Yamamoto,Noriyuki Inoue,Mayumi Ishikawa,Sumiyo Okada,Naomi Ishigaki,Hitoshi Iwasaki,Yuko Iwasaki,Tadayoshi Karasawa,Shin Kumadaki,Toshiyuki Matsui,Motohiro Sekiya,Ken Ohashi,Alyssa H. Hasty,Yoshimi Nakagawa,Akimitsu Takahashi,Hiroaki Suzuki,Sigeru Yatoh,Hirohito Sone,Hideo Toyoshima,Jun-ichi Osuga,Nobuhiro Yamada +26 more
TL;DR: Hepatic fatty acid composition is a new determinant for insulin sensitivity that acts independently of cellular energy balance and stress and could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
Tomohiro Yoshikawa,Hitoshi Shimano,Naoya Yahagi,Tomohiro Ide,Michiyo Amemiya-Kudo,Takashi Matsuzaka,Masanori Nakakuki,Sachiko Tomita,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Akimitsu Takahashi,Hirohito Sone,Jun-ichi Osuga,Takanari Gotoda,Shun Ishibashi,Nobuhiro Yamada +17 more
TL;DR: The data suggest that PUFAs could be deeply involved in nutritional regulation of cellular fatty acid levels by inhibiting an LXR-SREBP-1c system crucial for lipogenesis.
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