Nobuhiro Nishiyama
Tokyo Institute of Technology
300 Papers
1.8K Citations
Nobuhiro Nishiyama is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Micelle & Chemistry. The author has an hindex of 81, co-authored 269 publications. Previous affiliations of Nobuhiro Nishiyama include National Institute for Materials Science & University of Tokyo.
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Papers
pH-sensitive Assembly of Light-Harvesting Dendrimer Zinc Porphyrin Bearing Peripheral Groups of Primary Amine with Poly(ethylene glycol)-b-poly(aspartic acid) in Aqueous Solution
TL;DR: In this article, a light harvesting dendrimer zinc porphyrin [NH2CH2CH 2NHCO]32DPZn was synthesized and successfully assembled with poly(ethylene glycol)-b-poly(aspartic acid) to form micelles in PBS buffer (10 mM).
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Smart polymeric micelles as nanocarriers for oligonucleotides and siRNA delivery
Kazunori Kataoka,Keiji Itaka,Nobuhiro Nishiyama,Yuichi Yamasaki,Motoi Oishi,Yukio Nagasaki +5 more
- 01 Sep 2005
TL;DR: Three types of newly engineered block copolymers were developed to construct polyplex micelles useful for oligonucleotides and siRNA delivery and the construction of organic/inorganic hybrid nanoparticles encapsulating siRNA.
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Gelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for the development of functional collateral vessels.
Akihiro Hosaka,Hiroyuki Koyama,Toshihiro Kushibiki,Yasuhiko Tabata,Nobuhiro Nishiyama,Tetsuro Miyata,Hiroshi Shigematsu,Tsuyoshi Takato,Hirokazu Nagawa +8 more
TL;DR: IA administration of bFGF-impregnated, 29-&mgr;m-diameter AGHMs strongly induced functional collateral vessels without worsening ischemia, indicating the possible therapeutic usefulness of this approach.
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siRNA-Loaded Polyion Complex Micelle Decorated with Charge-Conversional Polymer Tuned to Undergo Stepwise Response to Intra-Tumoral and Intra-Endosomal pHs for Exerting Enhanced RNAi Efficacy
Montira Tangsangasaksri,Hiroyasu Takemoto,Mitsuru Naito,Yoshinori Maeda,Daiki Sueyoshi,Hyun Jin Kim,Yutaka Miura,Jooyeon Ahn,Ryota Azuma,Nobuhiro Nishiyama,Kanjiro Miyata,Kazunori Kataoka +11 more
TL;DR: The development of an siRNA-loaded polyion complex (PIC) micelle equipped with a smart polymeric shell featuring tumor targetability and endosome escapability for enhanced RNAi activity in cancer cells is developed, demonstrating that the acidic pH-responsive polypeptide shell is a promising design strategy for tumor-targeted siRNA delivery.
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Polymeric Micelle Drug Carrier Systems: PEG-PAsp(Dox) and Second Generation of Micellar Drugs
TL;DR: Polymeric micelles are one of the most refined and promising modalities of macromolecular drug delivery systems, and show unique disposition characteristics in the body suitable for the drug targeting.
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