Nobuhiko Mizuno
Osaka University
8 Papers
165 Citations
Nobuhiko Mizuno is an academic researcher from Osaka University. The author has contributed to research in topics: Transgene & Lens (anatomy). The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Nobuhiko Mizuno include University of Tokyo.
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Papers
FGF2 triggers iris-derived lens regeneration in newt eye.
TL;DR: It is shown that among various growth factors injected in an intact eye, a single injection of FGF2 specifically caused morphological changes of the iris characteristic of lens regeneration, induced expression of transcription factor genes Pax6, Sox2 and MafB, as well as endogenous Fgf2 in both dorsal and ventral halves, and provoked second lens development only from the dorsal iris.
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Determinative role of Wnt signals in dorsal iris-derived lens regeneration in newt eye.
Toshinori Hayashi,Nobuhiko Mizuno,Nobuhiko Mizuno,Ritsuko Takada,Shinji Takada,Hisato Kondoh +5 more
TL;DR: Observations indicate that dorsal-specific activation of Wnt2b determines the dorsally limited development of lens from the iris pigmented epithelium.
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Generation of transgenic newt Cynops pyrrhogaster for regeneration study.
TL;DR: The newt transgenesis technique described here is likely to be of wide use in monitoring and manipulating gene expression in the study of molecular mechanisms underlying tissue regeneration.
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Expression of crystallin genes in embryonic and regenerating newt lenses
TL;DR: The expression pattern of the crystallin genes in normal lens development fundamentally resembles that during lens regeneration, suggesting the absence of unique expression programs of crystallin gene for lens regeneration not found in ontogeny.
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Determinative roles of FGF and Wnt signals in iris-derived lens regeneration in newt eye.
TL;DR: It is concluded that the regulation of FGF2 and Wnt signals is a determinative of the iris‐derived lens regeneration in the newt eye.
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