Noah Spies
Massachusetts Institute of Technology
8 Papers
333 Citations
Noah Spies is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Inflammatory bowel disease & Medicine. The author has an hindex of 5, co-authored 5 publications.
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Papers
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
H. Rosaria Chiang,Lori W. Schoenfeld,J. Graham Ruby,Vincent C. Auyeung,Noah Spies,Daehyun Baek,Wendy K. Johnston,Carsten Russ,Shujun Luo,Joshua E. Babiarz,Robert Blelloch,Gary P. Schroth,Chad Nusbaum,David P. Bartel +13 more
TL;DR: In this paper, the authors sequenced 60 million small RNAs from mouse brain, ovary, testes, embryonic stem cells, three embryonic stages, and whole newborns.
Biased chromatin signatures around polyadenylation sites and exons
Noah Spies,Cydney B. Nielsen,Richard A. Padgett,Christopher B. Burge +3 more
- 01 Oct 2009
TL;DR: For example, this article observed strong nucleosome depletion around human polyadenylation sites (PAS) and enrichment just downstream of PAS, suggesting active marking of exon locations at the chromatin level.
333
TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway
TL;DR: High-throughput sequencing is used to analyze Argonaute-associated small RNAs (sRNAs) in both the presence and absence of Cid14, which prevents certain abundant RNAs from becoming substrates for theRNAi machinery, thereby freeing the RNAi machinery to act on its proper targets.
3′ UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblasts
TL;DR: Both the decay and translation rates were highly correlated for proximal and distal 3' UTR isoforms from the same genes, implying that in 3T3 cells, alternative 3'UTR sequences play a surprisingly small regulatory role compared to other mRNA regions.
Biased chromatin signatures around polyadenylation sites and exons.
TL;DR: Certain histone modifications were specifically enriched on exons, suggesting active marking of exon locations at the chromatin level, providing evidence for extensive functional connections between chromatin structure and RNA processing.