Ning Yu
Fudan University
15 Papers
23 Citations
Ning Yu is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Psoriasis. The author has an hindex of 4, co-authored 4 publications.
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Papers
Double-stranded RNA induces melanocyte death via activation of Toll-like receptor 3.
TL;DR: The data suggest that viral dsRNA stimulates TLR3 in human melanocytes and triggers the cellular apoptosis through autocrine of IFN‐β.
RNA released from necrotic keratinocytes upregulates intercellular adhesion molecule-1 expression in melanocytes.
TL;DR: It is demonstrated that in human melanocytes, TLR3 seems to be necessary for the upregulation of ICAM-1, and observed a dramatic increase in proinflammatory cytokine and chemokine transcripts, which suggested that RNA released from necrotic keratinocytes might act as an endogenousTLR3 ligand for the stimulation of ICam-1 and other proinflammatory gene expression in human pigmentocytes, which might be involved in the pathogenesis of vitiligo following skin physical trauma
21
IL-17A synergistically enhances TLR3-mediated IL-36γ production by keratinocytes: A potential role in injury-amplified psoriatic inflammation.
TL;DR: It is demonstrated that IL‐17A synergistically enhanced the dsRNA‐mediated IL‐36γ production through a p38 MAPK‐, NF‐κB–, and IκBζ‐dependent mechanism.
15
Measurement properties of the Patient Global Assessment numerical rating scale in moderate-to-severe psoriasis.
Ning Yu,Chen Peng,Jing Zhou,Junying Gu,Jinhua Xu,Xia Li,Xinling Bi,Hui Deng,Xin Li,Yangfeng Ding,Yuling Shi +10 more
TL;DR: In this article , a single-question 11-point Patient Global Assessment (PtGA) numeric rating scale (NRS) was validated in patients with plaque psoriasis in a prospective, multicenter, and observational registry.
11
TLR7-MyD88-DC-CXCL16 axis results neutrophil activation to elicit inflammatory response in pustular psoriasis
Jiajing Lu,Xiaoyuan Zhong,Chunyuan Guo,Ning Yu,Chen Peng,Yangfeng Ding,Xunxia Bao,Jing Zhou,Yuling Shi +8 more
TL;DR: In this article , the authors showed that the TLR7-MyD88-DC-CXCL16 axis is an important mechanism that promotes neutrophil migration to psoriasis-like skin lesions and stimulates the inflammatory response.