Ning Xie
University of British Columbia
26 Papers
96 Citations
Ning Xie is an academic researcher from University of British Columbia. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 15, co-authored 21 publications.
Chat about Author
Papers
Mechanisms of the androgen receptor splicing in prostate cancer cells.
TL;DR: It is demonstrated that RNA splicing of AR-V7 in response to ADT was closely associated with AR gene transcription initiation and elongation rates and splicing factor recruitment to AR pre-mRNA under ADT conditions.
307
SRRM4 Drives Neuroendocrine Transdifferentiation of Prostate Adenocarcinoma Under Androgen Receptor Pathway Inhibition.
Yinan Li,Nilgun Donmez,Nilgun Donmez,Cenk Sahinalp,Cenk Sahinalp,Ning Xie,Yuwei Wang,Hui Xue,Fan Mo,Himisha Beltran,Martin E. Gleave,Yuzhuo Wang,Yuzhuo Wang,Colin Collins,Colin Collins,Xuesen Dong +15 more
TL;DR: It is confirmed that SRRM4 drives NEPC progression, and a novel bioinformatics tool, comparative alternative splicing detection (COMPAS), is proposed as a potential therapeutic target for NEPC.
168
Expression and Function of the Progesterone Receptor in Human Prostate Stroma Provide Novel Insights to Cell Proliferation Control
Yue Yu,Liangliang Liu,Ning Xie,Hui Xue,Hui Xue,Ladan Fazli,Ralph Buttyan,Yuzhuo Wang,Yuzhuo Wang,Martin E. Gleave,Xuesen Dong,Xuesen Dong +11 more
TL;DR: Investigation of the expression and function of the progesterone receptor in the prostate found that PR plays an inhibitory role in prostate stromal cell proliferation.
83
CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer
Takuya Tsujino,Tomoaki Takai,Kunihiko Hinohara,Fu Gui,Takeshi Tsutsumi,Xiao Bai,Chenkui Miao,Chao Feng,Bin Gui,Zsofia Sztupinszki,Antoine Simoneau,Ning Xie,Ladan Fazli,Xuesen Dong,Haruhito Azuma,Atish D. Choudhury,Kent W. Mouw,Zoltan Szallasi,Lee Zou,Adam S. Kibel,Li Jia +20 more
TL;DR: The authors performed genome-wide CRISPR-Cas9 knockout screens in BRCA1/2-proficient prostate cancer cells and identified previously unknown genes whose loss has a profound impact on PARP inhibitor response.
Prostate stromal cells express the progesterone receptor to control cancer cell mobility.
Yue Yu,Jennifer Lee,Ning Xie,Estelle Li,Antonio Hurtado-Coll,Ladan Fazli,Michael E. Cox,Stephen R. Plymate,Martin E. Gleave,Xuesen Dong +9 more
TL;DR: Decreased expression of the progesterone receptor in cancer associated stroma may contribute to the elevated SDF-1 and IL-6 levels in prostate tumors and enhance prostate tumor progression.