The influence of different ultraviolet (UV-C) doses (0.103 and 0.305 J/cm2 ) was investigated by instrumental color parameters, pH, lipid, and protein oxidations, fatty acids (FA) composition and biogenic amines (BAs) in Nile tilapia fillets during 11 d at 4 ± 1 °C. The UV-C treatment increased (P 0.05) by UV-C light. Fillets treated with a low UV-C dose exhibited greater (P < 0.05) total polyunsaturated fatty acid (PUFA) than their untreated counterparts. Therefore, a low UV-C dose can be recommended in tilapia fillets as an alternative processing method to control pH and BAs, as well as improve the total PUFA amount and overall nutritional quality.

Impact of UV‐C Light on the Fatty Acid Profile and Oxidative Stability of Nile Tilapia (Oreochromis niloticus) Fillets

The efficiency of ozonated water as a disinfectant for removing microorganisms in freshwater fish was investigated. Nile tilapia samples (whole and fillets) were immersed in cold water (11°C), without ozone (0 ppm—control) and with ozone (0.5, 1.0, 1.5 ppm) for 0, 5, 10, and 15 min. Microbiological and physicochemical parameters were evaluated. The most efficient ozone concentration to reduce microbiological contamination of the whole tilapia was 1.5 ppm (88.25% of reduction) at 15 min of contact. Ozonated water at 1 and 1.5 ppm showed the greatest reduction (77.2 and 79.49%, respectively) in the fillet treatment. Neither the pH nor the color of fillets was influenced by ozonated water treatment; however, a small triggering of lipid oxidation process was observed by the increase in the TBARS value. These results prove that ozonated water was effective in reducing the microbial load and maintain the quality of fish, with low cost.

Practical applications
As an environmentally friendly disinfectant, ozone now is being studied as an alternative to chlorine sanitizers in many segments of the food industry. The use of ozone as a superficial disinfectant of meat surfaces has been reported in the fish industry. Few studies on the use of ozone in farmed freshwater fish have been reported. Ozonated water treatments improve the quality and extend the shelf life of fish. We evaluated and proved the microbial efficiency of ozonated water during Nile tilapia processing, and indicate that fillet quality was not adversely affected by ozone treatment.

Effect of aqueous ozone on microbial and physicochemical quality of Nile tilapia processing

Hemorrhagic stroke, specifically intracerebral hemorrhage (ICH), has been implicated in the development of persistent cognitive impairment, significantly compromising the quality of life for affected individuals. Nevertheless, the precise underlying mechanism remains elusive. Here, we report for the first time that the accumulation of iron within the hippocampus, distal to the site of ICH in the striatum, is causally linked to the observed cognitive impairment with both clinical patient data and animal model. Both susceptibility-weighted imaging (SWI) and quantitative susceptibility mapping (QSM) demonstrated significant iron accumulation in the hippocampus of ICH patients, which is far from the actual hematoma. Logistical regression analysis and multiple linear regression analysis identified iron level as an independent risk factor with a negative correlation with post-ICH cognitive impairment. Using a mouse model of ICH, we demonstrated that iron accumulation triggers an excessive activation of neural stem cells (NSCs). This overactivation subsequently leads to the depletion of the NSC pool, diminished neurogenesis, and the onset of progressive cognitive dysfunction. Mechanistically, iron accumulation elevated the levels of reactive oxygen species (ROS), which downregulated the expression of Itga3. Notably, pharmacological chelation of iron accumulation or scavenger of aberrant ROS levels, as well as conditionally overexpressed Itga3 in NSCs, remarkably attenuated the exhaustion of NSC pool, abnormal neurogenesis and cognitive decline in the mouse model of ICH. Together, these results provide molecular insights into ICH-induced cognitive impairment, shedding light on the value of maintaining NSC pool in preventing cognitive dysfunction in patients with hemorrhagic stroke or related conditions. 

Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural stem cell pool contributes to cognitive impairment after hemorrhagic stroke.

The effect of Ultraviolet radiation type C (UV-C) radiation (0.100 ± 0.010 J/cm2) on shelf life of Arapaima gigas fillets stored at 4 ± 1°C for 18 days was investigated. The samples were analyzed for total aerobic mesophilic bacteria (TAMB) counts; total aerobic psychrotrophic bacteria (TAPB) counts; Enterobacteriaceae; purge loss; pH; lipid oxidation; total volatile bases (TVB-N); ammonia; biogenic amines (BAs); and L*, a*, and b* values. UV-C radiation increased (P   0.05) in detrimental effects on lipid oxidation or a* and b* values. UV-C at 0.100 J/cm2 demonstrated a good potential for use in A. gigas fillets and, therefore, it could be applied at industrial scale.

Effect of the UV-C Radiation on Shelf Life of Vacuum-Packed Refrigerated Pirarucu (Arapaima gigas) Fillets

Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of a large number of cardiomyocytes (CMs), which the adult heart struggles to replenish due to its limited regenerative capacity. Consequently, this deficit in CMs often precipitates severe complications such as heart failure (HF), with whole heart transplantation remaining the sole definitive treatment option, albeit constrained by inherent limitations. In response to these challenges, the integration of bio-functional materials within cardiac tissue engineering has emerged as a groundbreaking approach with significant potential for cardiac tissue replacement. Bioengineering strategies entail fortifying or substituting biological tissues through the orchestrated interplay of cells, engineering methodologies, and innovative materials. Biomaterial scaffolds, crucial in this paradigm, provide the essential microenvironment conducive to the assembly of functional cardiac tissue by encapsulating contracting cells. Indeed, the field of cardiac tissue engineering has witnessed remarkable strides, largely owing to the application of biomaterial scaffolds. However, inherent complexities persist, necessitating further exploration and innovation. This review delves into the pivotal role of biomaterial scaffolds in cardiac tissue engineering, shedding light on their utilization, challenges encountered, and promising avenues for future advancement. By critically examining the current landscape, we aim to catalyze progress toward more effective solutions for cardiac tissue regeneration and ultimately, improved outcomes for patients grappling with cardiovascular ailments. 

pdf/advancements-in-tissue-engineering-for-cardiovascular-health-2acs35jxtz.pdf

Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Exosomes from young healthy human plasma promote functional recovery from intracerebral hemorrhage via counteracting ferroptotic injury.

Carbon monoxide (CO) has been applied to fish muscle for colour stability and consumer preference during frozen storage and transportation. This study compared the changes in aerobic plate counts (APC), pH, total volatile basic nitrogen (TVB-N), K-value, colour, and sensory analyses between CO-treated and untreated tilapia fillets stored in ice and refrigerated at 5°C up to 14 days. Except for Hunter a* value, the two test fillet groups resembled each other in the freshness quality profiles during storage although the initial levels of APC, pH, and K-value varied slightly. The CO-treated fillets had significantly higher a* values and higher freshness grading scores than that of the untreated fillets. Good correlationships among K-value, overall, colour and odour qualities were demonstrated. The shelf life was 8-9 days and 4-5 days stored in ice and refrigerated temperatures, respectively on the basis of sensory characteristics and K-values. The consumers surveyed in this study had a preference for tilapia fillets with enhanced red muscle color; however, it did not bias acceptability.

/pdf/the-impact-of-carbon-monoxide-treatment-on-biochemical-and-d8hheef9it.pdf

The Impact of Carbon-Monoxide Treatment on Biochemical and Sensorial Quality of Tilapia Fillet during Low Temperature Storage

Background Dietary nucleotides [inclusion adenosine 5’-monophosphate (AMP)] supplementation was shown to promote the feed intake of sows and increase the AMP content in their milk in our previous work, but whether AMP shapes the energy expenditure and lipid metabolism in mammals remains unknown. Here, we aimed to explore the effects and the related mechanism of dietary AMP supplementation on food intake, body composition, energy expenditure, and lipid metabolism in male mice. Methods 4-week-old C57BL/6 mice (After a 1-wk adaptation) were fed with basal diet and basal diet supplemented with 0.1% AMP, respectively. Animal food intake and body weight were monitored and after 4 weeks all animals were sacrificed to measure the body composition, energy expenditure and lipid metabolism changes. Results Compared with the control, the 0.1% AMP fed mice showed higher food intake while lower adipose weight. Intriguingly, dietary AMP supplementation was found to stimulate brown adipose tissue thermogenesis as evidenced by the increase in the uncoupling protein-1 level and the core temperature. Moreover, AMP supplementation was shown to promote white adipose tissue lipolysis as indicated by smaller lipid droplet size in mice. These results demonstrate that dietary AMP supplementation could enhance oxygen consumption and energy expenditure. Conclusions This study highlights the physiological importance of AMP supplementation in mediating food intake and energy expenditure and suggests its potential as an adjuvant therapy in preventing energy metabolic disorders (mainly obesity and diabetes).

Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice

α-Mangostin suppresses proliferation and invasion in osteosarcoma cells via inhibiting fatty acid synthase

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Exosomes from young healthy human plasma promote functional recovery from intracerebral hemorrhage via counteracting ferroptotic injury.

The Impact of Carbon-Monoxide Treatment on Biochemical and Sensorial Quality of Tilapia Fillet during Low Temperature Storage

Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice

α-Mangostin suppresses proliferation and invasion in osteosarcoma cells via inhibiting fatty acid synthase