Ning Du
Xi'an Jiaotong University
36 Papers
118 Citations
Ning Du is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Cancer & Stem cell. The author has an hindex of 15, co-authored 30 publications.
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Papers
Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells
Xuejun Sun,Chongwen Xu,Shou Ching Tang,Jiansheng Wang,Huangzhen Wang,Peili Wang,Ning Du,Sida Qin,Gang Li,Shaohua Xu,Zhen Tao,Dapeng Liu,Hong Ren +12 more
TL;DR: These findings identified a biochemical and functional link between let-7c with ERα/Wnt signaling in breast cancer stem cells and found that higher expression levels of let- 7b and let-8c were correlated with better clinical prognosis of patients with estrogen receptor (ER)α-positive breast tumor.
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MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer.
Yamei Pang,Jian Liu,Xiang Li,Guodong Xiao,Huangzhen Wang,Ganghua Yang,Yanbo Li,Shou Ching Tang,Shou Ching Tang,Sida Qin,Ning Du,Henggang Zhang,Dapeng Liu,Xin Sun,Hong Ren +14 more
TL;DR: Findings reveal that MYC can collaborate with DNMT3A on inducing promoter methylation and miR‐200b silencing, and thereby promotes the epithelial to mesenchymal transition and mammosphere formation of TNBC cells.
77
CDH1 promoter methylation correlates with decreased gene expression and poor prognosis in patients with breast cancer
Jian Liu,Xin Sun,Sida Qin,Huangzhen Wang,Ning Du,Yanbo Li,Yamei Pang,Cuicui Wang,Chongwen Xu,Hong Ren +9 more
TL;DR: The present study suggests that CDH1 promoter methylation may be correlated with breast carcinogenesis and indicates poor prognosis in patients with breast cancer.
Let-7: a regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells.
TL;DR: The suppression of ERα by the upregulation of let-7 expression may be a promising strategy for the inhibition of the ER signaling pathway and for the elimination of cancer stem cells, thus aiding in the treatment of breast cancer.
A miR-26a/E2F7 feedback loop contributes to tamoxifen resistance in ER-positive breast cancer
Jian Liu,Xiang Li,Meng Wang,Guodong Xiao,Ganghua Yang,Huangzhen Wang,Yanbo Li,Xin Sun,Sida Qin,Ning Du,Hong Ren,Yamei Pang +11 more
TL;DR: The present study demonstrated that miR-26a expression was reduced in ER-positive breast cancer compared with in normal breast tissues, whereas E2F7 expression was significantly elevated, and revealed that a feedback loop between miR -26a and E2f7 may promote TAM resistance in ER, positive breast cancer.