Nils Bäck
University of Helsinki
47 Papers
575 Citations
Nils Bäck is an academic researcher from University of Helsinki. The author has contributed to research in topics: Endosome & Pituitary gland. The author has an hindex of 19, co-authored 47 publications. Previous affiliations of Nils Bäck include Helsinki University Central Hospital.
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Papers
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids
Riikka Hynynen,Monika Suchanek,Johanna Spandl,Nils Bäck,Christoph Thiele,Vesa M. Olkkonen,Vesa M. Olkkonen +6 more
TL;DR: Oxysterol binding protein-related protein 2 (ORP2) has been shown to be a sterol receptor present on cytoplasmic lipid droplets (LDs) as mentioned in this paper.
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Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins.
TL;DR: V-ATPase has a role in protein sorting in immature granules that is distinct from its role in acidification, which is essential for proteolytic processing of prohormones and aggregation of soluble content proteins.
NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.
Vilja Pietiäinen,Boris Vassilev,Boris Vassilev,Tomas Blom,Tomas Blom,Wei Wang,Wei Wang,Jessica K. Nelson,Robert Bittman,Nils Bäck,Noam Zelcer,Elina Ikonen,Elina Ikonen +12 more
TL;DR: It is reported that NDRG1 silencing in epithelial cells results in decreased uptake of low-density lipoprotein (LDL) due to reduced LDL receptor (LDLR) abundance at the plasma membrane, and co-depletion of IDOL, which ubiquitylates the LDLR and promotes its degradation, rescues plasma membrane LDLR levels and LDL uptake.
LAPTM4B facilitates late endosomal ceramide export to control cell death pathways
Tomas Blom,Tomas Blom,Shiqian Li,Shiqian Li,Andrea Dichlberger,Andrea Dichlberger,Nils Bäck,Young Ah Kim,Ursula Loizides-Mangold,Howard Riezman,Robert Bittman,Elina Ikonen,Elina Ikonen +12 more
TL;DR: Novel ceramide probes are used to provide evidence that LAPTM4B interacts with ceramide and facilitates its removal from late endosomal organelles (LEs) and uncover a cellular ceramide export route from LEs and identify LAP TM4B as its regulator.
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Kalirin, a Multifunctional PAM COOH-terminal Domain Interactor Protein, Affects Cytoskeletal Organization and ACTH Secretion from AtT-20 Cells
Richard E. Mains,M. Rashidul Alam,Richard C. Johnson,Daniel N. Darlington,Nils Bäck,T. Hand,Betty A. Eipper +6 more
TL;DR: Peptidylglycine α-amidating monooxygenase (PAM), an enzyme essential for biosynthesis of many peptides, is an integral membrane protein with trafficking information in both its lumenal and cytosol domains, and the PAM-Kalirin interaction may coordinate intragranular with cytosolic events.
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