Nils B. Becker
German Cancer Research Center
21 Papers
10 Citations
Nils B. Becker is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 5, co-authored 13 publications. Previous affiliations of Nils B. Becker include Heidelberg University.
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Papers
Phenotypic memory in Bacillus subtilis links dormancy entry and exit by a spore quantity-quality tradeoff.
Alper Mutlu,Stephanie Trauth,Stephanie Trauth,Marika Ziesack,Katja Nagler,Katja Nagler,Jan Philip Bergeest,Jan Philip Bergeest,Karl Rohr,Karl Rohr,Nils B. Becker,Nils B. Becker,Thomas Höfer,Thomas Höfer,Ilka B. Bischofs,Ilka B. Bischofs +15 more
TL;DR: A theoretical analysis and experiments with signaling mutants exhibiting altered sporulation timing support the hypothesis that such an intrinsically generated memory leads to a tradeoff between spore quantity and spore quality, which could drive the emergence of complex microbial traits.
Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis
Mina Morcos,Congxin Li,Clara M. Munz,A. Greco,N. Dressel,Susanne Reinhardt,Katrin Sameith,Andreas Dahl,Nils B. Becker,Axel Roers,Thomas Höfer,Alexander Gerbaulet +11 more
TL;DR: In this paper , the authors chart native lineage pathways emanating from HSCs and define their physiological regulation by computationally integrating experimental approaches for fate mapping, mitotic tracking, and single-cell RNA sequencing.
A spore quality-quantity tradeoff favors diverse sporulation strategies in Bacillus subtilis.
Alper Mutlu,Alper Mutlu,Charlotte Kaspar,Charlotte Kaspar,Nils B. Becker,Nils B. Becker,Ilka B. Bischofs,Ilka B. Bischofs +7 more
TL;DR: It is shown both theoretically and experimentally that the nutrient supply during spore revival determines the fitness advantage associated with different sporulation behaviors in Bacillus subtilis.
Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees.
Erika E Kuchen,Erika E Kuchen,Nils B. Becker,Nils B. Becker,Nina Claudino,Nina Claudino,Thomas Höfer,Thomas Höfer +7 more
TL;DR: It is shown how fluctuations of cell cycles across lineage trees help in understanding the coordination of cell growth and division.
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Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development
Stefan Scherer,Susanne Oberle,Kristiyan Kanev,Ann-Katrin Gerullis,Ming Wu,Gustavo P. de Almeida,Daniel J. Puleston,Francesc Baixauli,Lilian Aly,A. Greco,T. Nizharadze,Nils B. Becker,Madlaina V Hoesslin,Lara V Donhauser,Jacqueline Berner,Talyn Chu,Hayley A. McNamara,Zeynep Esencan,Patrick Roelli,Christine Wurmser,Ingo Kleiter,Maria J G T Vehreschild,Christoph Mayer,Percy A. Knolle,Martin Klingenspor,Valeria Fumagalli,Matteo Iannacone,Martin Prlic,Thomas Korn,Erika L. Pearce,Thomas Höfer,Anna Maria Schulz,Dietmar Zehn +32 more
TL;DR: This paper showed that memory T cell precursors are resistant to pyrimidine starvation, which is a drug-targetable checkpoint that efficiently diminishes effector T cells without affecting the memory compartment.
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