Nili Dezorella
Weizmann Institute of Science
24 Papers
54 Citations
Nili Dezorella is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Biology & Chronic lymphocytic leukemia. The author has an hindex of 8, co-authored 15 publications. Previous affiliations of Nili Dezorella include Tel Aviv Sourasky Medical Center.
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Papers
Golgi organization is regulated by proteasomal degradation.
Avital Eisenberg-Lerner,Ron Benyair,Noa Hizkiahou,Neta Nudel,Roey Maor,Matthias P. Kramer,Merav D. Shmueli,Inbal Zigdon,Marina Cherniavsky Lev,Adi Ulman,Jitka Yehudith Sagiv,Molly Dayan,Bareket Dassa,Mercedes Rosenwald,Idit Shachar,Jie Li,Yanzhuang Wang,Nili Dezorella,Suman Khan,Ziv Porat,Eyal Shimoni,Ori Avinoam,Yifat Merbl +22 more
TL;DR: Stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal is identified, providing a functional link between proteostasis control and Golgi architecture, which may be critical in various secretion-related pathologies.
Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas.
Lydia Farack,Matan Golan,Adi Egozi,Nili Dezorella,Keren Bahar Halpern,Shani Ben-Moshe,Immacolata Garzilli,Beáta Tóth,Lior Roitman,Valery Krizhanovsky,Shalev Itzkovitz +10 more
TL;DR: An optimized protocol for single-molecule transcript imaging in the intact pancreas is developed and used to identify a sub-population of "extreme" beta cells with elevated mRNA levels of insulin and other secretory genes, suggesting they may be tuned for basal insulin secretion.
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CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia
Hadas Lewinsky,Avital F. Barak,Victoria Huber,Matthias P. Kramer,Lihi Radomir,Lital Sever,Irit Orr,Vita Mirkin,Nili Dezorella,Mika Shapiro,Yosef Cohen,Lev Shvidel,Martina Seiffert,Yair Herishanu,Shirly Becker-Herman,Idit Shachar +15 more
TL;DR: A role for CD84 is demonstrated in the regulation of immune checkpoints by leukemia cells and CD84 blockade is identified as a therapeutic strategy to reverse tumor-induced immune suppression.
Parallel evolution of cannabinoid biosynthesis
Paula Berman,Luis Alejandro de Haro,Adam Jozwiak,Sayantan Panda,Jelena Cvetićanin,Ranjit S. Barbole,Tali Scherf,Eyal Shimoni,Smadar Levin-Zaidman,Nili Dezorella,Ekaterina Petrovich-Kopitman,Sagit Meir,Ilana Rogachev,Prashant D. Sonawane,Asaph Aharoni +14 more
TL;DR: A cannabinoid biosynthetic pathway is revealed in Helichrysum umbraculigerum, a plant genetically distant from Cannabis, providing a potential source of new cannabinoids and metabolic engineering tools and tools for engineering in heterologous hosts.
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Mesenchymal stromal cells revert multiple myeloma cells to less differentiated phenotype by the combined activities of adhesive interactions and interleukin-6.
Nili Dezorella,Meirav Pevsner-Fischer,Varda Deutsch,Sigi Kay,Shoshana Baron,Ruth Stern,Sigal Tavor,Arnon Nagler,Arnon Nagler,Elizabeth Naparstek,Elizabeth Naparstek,Dov Zipori,Ben Zion Katz,Ben Zion Katz +13 more
TL;DR: Overall, the data indicate that the bone marrow-derived mesenchymal stromal cells revert multiple myeloma cells to less differentiated phenotype by the combined activities of adhesive interactions and interleukin-6.
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