Nikolaus Sonnenschein
Technical University of Denmark
59 Papers
118 Citations
Nikolaus Sonnenschein is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 20, co-authored 46 publications. Previous affiliations of Nikolaus Sonnenschein include University of California, San Diego & Novo Nordisk Foundation.
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Papers
Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing
Christian Lieven,Moritz Emanuel Beber,Brett G. Olivier,Frank Bergmann,Meriç Ataman,Parizad Babaei,Jennifer A. Bartell,Lars M. Blank,Siddharth Chauhan,Kevin Correia,Christian Diener,Christian Diener,Andreas Dräger,Birgitta E. Ebert,Birgitta E. Ebert,Janaka N. Edirisinghe,José P. Faria,Adam M. Feist,Adam M. Feist,Georgios Fengos,Ronan M. T. Fleming,Beatriz García-Jiménez,Beatriz García-Jiménez,Vassily Hatzimanikatis,Wout van Helvoirt,Wout van Helvoirt,Christopher S. Henry,Henning Hermjakob,Markus J. Herrgård,Ali Kaafarani,Hyun Uk Kim,Zachary A. King,Steffen Klamt,Edda Klipp,Jasper J. Koehorst,Matthias König,Meiyappan Lakshmanan,Dong-Yup Lee,Dong-Yup Lee,Sang Yup Lee,Sang Yup Lee,Sunjae Lee,Sunjae Lee,Nathan E. Lewis,Filipe Liu,Hongwu Ma,Daniel Machado,Radhakrishnan Mahadevan,Paulo Maia,Adil Mardinoglu,Adil Mardinoglu,Gregory L. Medlock,Jonathan Monk,Jens Nielsen,Jens Nielsen,Lars K. Nielsen,Lars K. Nielsen,Juan Nogales,Intawat Nookaew,Intawat Nookaew,Bernhard O. Palsson,Bernhard O. Palsson,Jason A. Papin,Kiran Raosaheb Patil,Mark G. Poolman,Nathan D. Price,Osbaldo Resendis-Antonio,Anne Richelle,Isabel Rocha,Isabel Rocha,Benjamin Sanchez,Benjamin Sanchez,Peter J. Schaap,Rahuman S. Malik Sheriff,Saeed Shoaie,Saeed Shoaie,Nikolaus Sonnenschein,Bas Teusink,Paulo Vilaça,Jon Olav Vik,Judith A. H. Wodke,Joana C. Xavier,Qianqian Yuan,Maksim Zakhartsev,Cheng Zhang +84 more
TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
MARSI: metabolite analogues for rational strain improvement
João Gonçalo Rocha Cardoso,Ahmad A. Zeidan,Kristian Jensen,Nikolaus Sonnenschein,Ana Rute Neves,Markus J. Herrgård +5 more
TL;DR: The designs found by MARSI can be implemented by supplying MAs in the culture media, enabling metabolic rewiring without the use of recombinant DNA technologies that cannot always be used due to regulations.
Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies
Ibrahim E. Elsemman,Ibrahim E. Elsemman,Rodrigues Prado A,Pranas Grigaitis,Garcia Albornoz M,Harman,Stephen W. Holman,van Heerden J,Frank J. Bruggeman,Bisschops Mmm,Nikolaus Sonnenschein,Simon J. Hubbard,Robert J. Beynon,Pascale Daran-Lapujade,Jens Nielsen,Jens Nielsen,Bas Teusink +16 more
TL;DR: In this article, the authors developed a comprehensive metabolic model of the yeast cell, based on its full metabolic reaction network extended with protein synthesis and degradation reactions (16304 reactions in total).
CRI-SPA: a high-throughput method for systematic genetic editing of yeast libraries.
Paul Cachera,Helén Olsson,H. Coumou,Mads L. Jensen,Benjamin Sanchez,Tomas Strucko,Marcel van den Broek,Jean-Marc Daran,Michael Krogh Jensen,Nikolaus Sonnenschein,Michael Lisby,Uffe Hasbro Mortensen +11 more
TL;DR: The results provide a genome-wide overview of the genetic requirements for betaxanthin production and envision that the simplicity, speed, and reliability offered by CRI-SPA will make it a versatile tool to forward systems-level understanding of biological processes.
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Emergence of phenotypically distinct subpopulations is a factor in adaptation of recombinant Saccharomyces cerevisiae under glucose-limited conditions
Naia Risager Wright,Tune Wulff,Christopher T. Workman,Nanna Petersen Rønnest,Nikolaus Sonnenschein +4 more
TL;DR: In this article, the authors investigated the adaptation at the single-cell level by application of FACS and showed that three apparent phenotypes underlie the adaptive response observed at the bulk level: (1) cells that drastically reduced insulin production, (2) cells with reduced enzymatic capacity in central carbon metabolism and pseudohyphal growth.