Niklas Vesper
University of Freiburg
5 Papers
11 Citations
Niklas Vesper is an academic researcher from University of Freiburg. The author has contributed to research in topics: Antibody & Immune system. The author has an hindex of 1, co-authored 5 publications.
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Papers
A symmetric geometry of transmembrane domains inside the B cell antigen receptor complex.
Cornelia Gottwick,Xiaocui He,Xiaocui He,Andreas Hofmann,Andreas Hofmann,Niklas Vesper,Michael Reth,Jianying Yang,Jianying Yang +8 more
TL;DR: It is described that Igα and Igβ both carry on one side of their α-helical transmembrane domain a conserved amino acid motif that is required for the retention of unassembled Igα or Igβ molecules inside the endoplasmic reticulum and the binding of the Igα/Igβ heterodimer to the mIg molecule.
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A Barcoded Flow Cytometric Assay to Explore the Antibody Responses Against SARS-CoV-2 Spike and Its Variants.
Niklas Vesper,Yaneth Ortiz,Frauke Bartels-Burgahn,Jianying Yang,Kathrin de la Rosa,Matthias Tenbusch,Sebastian R. Schulz,Stephanie Finzel,Hans-Martin Jäck,Hermann Eibel,Reinhard E. Voll,Michael Reth +11 more
TL;DR: In this paper, a color-based barcoded spike flow cytometric assay (BSFA) was proposed to evaluate and directly compare the humoral immune response directed against either wild type (WT) or mutant spike (S) proteins or the receptor-binding domains (RBD) of SARS-CoV-2.
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finDr: A web server for in silico D-peptide ligand identification
Helena Engel,Felix Guischard,Fabian Krause,Janina Nandy,Paulina Kaas,Nico Höfflin,Maja Köhn,Normann Kilb,Karsten Voigt,Steffen Wolf,Tahira Aslan,Fabian Baezner,Salomé Hahne,Carolin Ruckes,Joshua Weygant,Alisa Zinina,Emir Bora Akmeriç,Enoch B. Antwi,Dennis Dombrovskij,Philipp Franke,Klara L. Lesch,Niklas Vesper,Daniel Georg Weis,Nicole Gensch,Barbara Di Ventura,Mehmet Ali Öztürk +25 more
TL;DR: FinDr as mentioned in this paper is a web server for the computational identification and optimization of D-peptide ligands to any protein structure ( https://findr.biologie.uni-freiburg.de/ ).
5
A surrogate cell-based SARS-CoV-2 spike blocking assay.
Wolfgang Schuh,Lena Baus,Tobit Steinmetz,Sebastian R. Schulz,Leonie Weckwerth,Edith Roth,Manuela Hauke,Sara Krause,Patrick Morhart,Manfred Rauh,Markus Hoffmann,Markus Hoffmann,Niklas Vesper,Michael Reth,Holm Schneider,Hans-Martin Jäck,Dirk Mielenz +16 more
TL;DR: In this article, a fast and inexpensive surrogate SARS-CoV-2 blocking assay (SUBA) was developed using immobilized recombinant human angiotensin-converting enzyme 2 (hACE2) and human cells expressing the native form of surface SARS CoV2 spike protein.
4
Engineered chimeric T cell receptor fusion construct (TRuC)-expressing T cells prevent translational shutdown in SARS-CoV-2-infected cells
Godbole I,Kevin Ciminski,Omid Sascha Yousefi,Pathan-Chhatbar S,Saltukoglu D,Niklas Vesper,Salavei P,Strietz J,Gensch N,Michael Reth,Martin Schwemmle,Wolfgang W. A. Schamel +11 more
TL;DR: In this paper, an S-binding domain is fused to the CD3{varepsilon} component of the T cell receptor (TCR) complex, enabling recognition of S-containing cells in an HLA independent manner.