Nikhil Kumar
University of Maryland, Baltimore
31 Papers
123 Citations
Nikhil Kumar is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 20, co-authored 29 publications. Previous affiliations of Nikhil Kumar include J. Craig Venter Institute.
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Papers
Widespread Lateral Gene Transfer from Intracellular Bacteria to Multicellular Eukaryotes
Julie C. Dunning Hotopp,Michael E. Clark,Deodoro C. S. G. Oliveira,Jeremy M. Foster,Peter Fischer,Monica C. Muñoz Torres,Jonathan D. Giebel,Nikhil Kumar,Nadeeza Ishmael,Shiliang Wang,Jessica Ingram,Rahul V. Nene,Jessica Shepard,Jeffrey P. Tomkins,Stephen Richards,David J. Spiro,Elodie Ghedin,Elodie Ghedin,Barton E. Slatko,Hervé Tettelin,John H. Werren +20 more
TL;DR: It is shown that some of these inserted Wolbachia genes are transcribed within eukaryotic cells lacking endosymbionts, potentially providing a mechanism for acquisition of new genes and functions.
Genome-Wide Identification of Genes Required for Fitness of Group A Streptococcus in Human Blood
Yoann Le Breton,Pragnesh Mistry,Kayla M. Valdes,Jeffrey Quigley,Nikhil Kumar,Hervé Tettelin,Kevin S. McIver +6 more
TL;DR: This work represents the first use of TraSH in GAS to identify potential virulence genes, including those encoding the virulence regulator Mga, the peroxide response regulator PerR, and the RofA-like regulator Ralp-3.
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Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production
Carlos J. Sanchez,Nikhil Kumar,Anel Lizcano,Pooja Shivshankar,Julie C. Dunning Hotopp,James H. Jorgensen,Hervé Tettelin,Carlos J. Orihuela +7 more
TL;DR: It is suggested that biofilms do not directly contribute to development of IPD and may instead confer a quiescent mode of growth during colonization.
Whole genome shotgun sequencing of Brassica oleracea and its application to gene discovery and annotation in Arabidopsis
Mulu Ayele,Brian J. Haas,Nikhil Kumar,Hank C. Wu,Yongli Xiao,Susan Van Aken,Teresa Utterback,Jennifer R. Wortman,Owen White,Christopher D. Town +9 more
TL;DR: Comparative studies of the model organism Arabidopsis thaliana and its close relative Brassica oleracea have identified conserved regions that represent potentially functional sequences overlooked by previousArabidopsis genome annotation methods, and suggest that several thousand new Arabidops genes remain to be identified and annotated.
Variation in the Group B Streptococcus CsrRS Regulon and Effects on Pathogenicity
Shengmei Jiang,Shengmei Jiang,Nadeeza Ishmael,Julie C. Dunning Hotopp,Manuela Puliti,Luciana Tissi,Nikhil Kumar,Michael J. Cieslewicz,Michael J. Cieslewicz,Hervé Tettelin,Michael R. Wessels,Michael R. Wessels +11 more
TL;DR: It is concluded that CsrRS regulates a core group of genes including important virulence factors in diverse strains of GBS but also displays marked variability in the repertoire of regulated genes and in the relative effects of CsrS signaling on CsrR-mediated gene regulation.
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