Nigel Smith
Nottingham City Hospital
8 Papers
149 Citations
Nigel Smith is an academic researcher from Nottingham City Hospital. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Nigel Smith include Nottingham University Hospitals NHS Trust & Leicester General Hospital.
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Papers
Automated, scalable culture of human embryonic stem cells in feeder‐free conditions
Robert Thomas,David A. Anderson,Amit Chandra,Nigel Smith,Lorraine E. Young,David J. Williams,Chris Denning +6 more
TL;DR: It is demonstrated that passaging of the hESC lines, HUES7, and NOTT1, with trypsin in feeder‐free conditions, is compatible with complete automation on the CompacT SelecT, a commercially available and industrially relevant robotic platform.
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Common culture conditions for maintenance and cardiomyocyte differentiation of the human embryonic stem cell lines, BG01 and HUES-7.
Chris Denning,Cinzia Allegrucci,Helen Priddle,Maria D Barbadillo-Muñoz,David A. Anderson,Tim Self,Nigel Smith,C Tony Parkin,Lorraine E. Young +8 more
TL;DR: The same culture and differentiation conditions functioned in two independently-derived hESC lines, and derived cardiomyocytes expressed cardiac genes and responded to pharmacological stimulation.
17q12 microdeletion syndrome: three patients illustrating the phenotypic spectrum.
Abhijit Dixit,Chirag Patel,Rachel Harrison,Joanna Jarvis,Sally A. Hulton,Nigel Smith,Katherine Yates,Lee Silcock,Dominic J. McMullan,Mohnish Suri +9 more
TL;DR: It is suggested that while patients with 17q12 microdeletion syndrome can present with type 2 diabetes or renal cysts without any dysmorphic features, a subgroup may have dys morphic features or present with neonatal cholestasis.
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Derivation and characterisation of the human embryonic stem cell lines, NOTT1 and NOTT2
Helen Priddle,Cinzia Allegrucci,Paul W. Burridge,Maria D. Barbadillo Muñoz,Nigel Smith,Lyndsey Devlin,Cecilia Sjoblom,Sarah Chamberlain,Susan A. Watson,Lorraine E. Young,Chris Denning +10 more
TL;DR: Observations show that NOTT1 and NOTT2 display the accepted characteristics of hESC pluripotency.
Mild phenotype in a patient with a de-novo 2.9-Mb interstitial deletion at 13q12.11.
TL;DR: A 16-year-old boy with a de-novo 2.9-Mb interstitial deletion at 13q12 is described, with previously unreported breakpoints and a relatively mild phenotype with a degree of facial dysmorphism, scaphocephaly, torticollis and near normal development and intellect.
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