Nigel Halliday
University of Nottingham
47 Papers
194 Citations
Nigel Halliday is an academic researcher from University of Nottingham. The author has contributed to research in topics: Quorum sensing & Pseudomonas aeruginosa. The author has an hindex of 16, co-authored 39 publications.
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Papers
Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis.
Helen L. Barr,Nigel Halliday,Miguel Cámara,David A. Barrett,Paul Williams,Douglas L Forrester,Rebecca Simms,Alan R. Smyth,David Honeybourne,Joanna L. Whitehouse,Edward F. Nash,Jane Dewar,Andrew Clayton,Alan J. Knox,Andrew W. Fogarty +14 more
TL;DR: Quorum sensing signal molecules are detectable in cystic fibrosis patients with pulmonary P. aeruginosa infection and are positively correlated with quantitative measures of P. Aerug inosa infection, which indicates that NHQ correlates with clinical status and has potential as a novel biomarker for P.aerugInosa infection.
104
Identification of FDA-Approved Drugs as Antivirulence Agents Targeting the pqs Quorum-Sensing System of Pseudomonas aeruginosa
Francesca D'Angelo,Valerio Baldelli,Nigel Halliday,Paolo Pantalone,Fabio Polticelli,Ersilia Fiscarelli,Paul Williams,Paolo Visca,Livia Leoni,Giordano Rampioni +9 more
TL;DR: The most active inhibitor, clofoctol, specifically inhibited the expression of pqs-controlled virulence traits in P. aeruginosa, such as pyocyanin production, swarming motility, biofilm formation, and expression of genes involved in siderophore production.
98
LuxS-independent formation of AI-2 from ribulose-5-phosphate
Timothy J. Tavender,Timothy J. Tavender,Nigel Halliday,Kim R. Hardie,Klaus Winzer,Klaus Winzer +5 more
TL;DR: It is suggested that LuxS-independent formation of AI-2, via spontaneous conversion of ribulose-5-phosphate, may indeed occur in vivo, and does not contribute toAI-2 formation in wildtype E. coli and S. aureus under the conditions tested.
Growth Deficiencies of Neisseria meningitidis pfs and luxS Mutants Are Not Due to Inactivation of Quorum Sensing
Karin Heurlier,Agnès Vendeville,Nigel Halliday,Andrew Green,Andrew Green,Klaus Winzer,Klaus Winzer,Christoph M. Tang,Kim R. Hardie +8 more
TL;DR: In this paper, it was shown that the Pfs reaction is the sole intracellular source of the AI-2 signal in Neisseria meningitidis mutants, and that the observed growth defect is not due to quorum sensing but is probably due to metabolic imbalance and, in the case of pfs activation, is most likely due to toxic accumulation of SAH.
44
The fitness burden imposed by synthesising quorum sensing signals
Avika Ruparell,Jean-Frédéric Dubern,Cartherine A Ortori,Freya Harrison,Nigel Halliday,Abigail L. Emtage,Mahmoud Ashawesh,Charles A. Laughton,Steve Diggle,Paul Williams,David A. Barrett,Kim R. Hardie +11 more
TL;DR: The data identify the sources of the fitness costs incurred by QSSM producer cells, and indicate that there may be metabolic trade-offs associated with QS signaling that could exert selection on how signaling evolves.