Nigel A. Brown
St George's, University of London
153 Papers
1.4K Citations
Nigel A. Brown is an academic researcher from St George's, University of London. The author has contributed to research in topics: Biology & Population. The author has an hindex of 51, co-authored 153 publications. Previous affiliations of Nigel A. Brown include St George's Hospital & National Institutes of Health.
Chat about Author
Papers
The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm.
TL;DR: Analysis of a transgenic mouse line in which beta-galactosidase activity is observed in the embryonic right ventricle and outflow tract of the heart and in contiguous splanchnic and pharyngeal mesoderm suggests that arterial pole myocardium originates outside the classical heart field.
848
Quantitation of rat embryonic development in vitro: a morphological scoring system
TL;DR: Use of the morphological scoring system in embryo culture experiments provides a precise index of embryonic development, aids the detection of retardation or dysmorphogenesis of specific primordia, and allows a quantitative comparison of development and growth.
519
The development of handedness in left/right asymmetry.
Nigel A. Brown,Lewis Wolpert +1 more
TL;DR: A model for the development of handedness in bilateral animals, comprising three components, can explain the abnormal development ofhandedness observed in bisected embryos of some mammalian, amphibian and sub-vertebrate species.
423
The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods
Elke Genschow,Horst Spielmann,Gabriele Scholz,Andrea Seiler,Nigel A. Brown,Aldert H. Piersma,Madeleine Brady,Nicole Clemann,Hannele Huuskonen,Francoise Paillard,Susanne Bremer,K. Becker +11 more
TL;DR: The three in vitro embryotoxicity tests proved to be applicable to testing a diverse group of chemicals with different embryotoxic potentials (non-embryotoxic, weakly embryot toxic, and strongly embryot Toxic) and to define new biostatistically based prediction models (PMs) for the MM and WEC tests.
409
Molecular Pathway for the Localized Formation of the Sinoatrial Node
Mathilda T.M. Mommersteeg,Willem M.H. Hoogaars,Owen W.J. Prall,Corrie de Gier-de Vries,Cornelia Wiese,Danielle E.W. Clout,Virginia E. Papaioannou,Nigel A. Brown,Richard P. Harvey,Antoon F.M. Moorman,Vincent M. Christoffels +10 more
TL;DR: The molecular pathway provides a mechanism for how pacemaker activity becomes progressively relegated to the most recently added components of the venous pole of the heart and, ultimately, to the junction of the right atrium and superior caval vein.
385