Nicole Wagner
Schering-Plough
6 Papers
53 Citations
Nicole Wagner is an academic researcher from Schering-Plough. The author has contributed to research in topics: Chemokine receptor & Viral load. The author has an hindex of 4, co-authored 6 publications.
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Papers
Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5
Vinod R. Hegde,Tze-Ming Chan,Haiyan Pu,Vincent P. Gullo,Mahesh Patel,Pradip R. Das,Nicole Wagner,P. S. Parameswaran,C.G. Naik +8 more
TL;DR: The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2, suggesting their selectivity for the CCR5 receptor.
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Biological evaluation and interconversion studies of rotamers of SCH 351125, an orally bioavailable CCR5 antagonist.
Anandan Palani,Sherry Shapiro,John W. Clader,William J. Greenlee,David J. Blythin,Kathleen Cox,Nicole Wagner,Julie M. Strizki,Bahige M. Baroudy,Niya Dan +9 more
TL;DR: The separation and biological evaluation of rotamers as well as interconversion studies on rotamer of the authors' clinical candidate SCH 351125 are described.
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Two Selective Novel Triterpene Glycosides from Sea Cucumber, Telenata Ananas: Inhibitors of Chemokine Receptor‐5
Vinod R. Hegde,Tze-Ming Chan,Haiyan Pu,Vincent P. Gullo,Mahesh Patel,Pradip R. Das,Nicole Wagner,P. S. Parameswaran,C.G. Naik +8 more
TL;DR: In this paper, the aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2, which exhibited inhibitory activity (K(i)) of 30 and 5microM, respectively, in a chemokine receptor subtype 5 (CCR5) assay.
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Sch 213766, a Novel Chemokine Receptor CCR-5 Inhibitor from Chaetomium globosum.
Shu‐Wei Yang,Ronald Mierzwa,Joseph Terracciano,Mahesh Patel,Vincent P. Gullo,Nicole Wagner,Bahige M. Baroudy,Mohindar S. Puar,Tze-Ming Chan,Min Chu +9 more
TL;DR: A fungal secondary metabolite, Sch 213766 was isolated from the fungal fermentation broth of Chaetomium globosum as the chemokine receptor CCR-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid Sch 210972 on the basis of UV, MS and NMR spectral data analyses as mentioned in this paper.
Sch 213766, a novel chemokine receptor CCR-5 inhibitor from Chaetomium globosum.
Shu‐Wei Yang,Ronald Mierzwa,Joseph Terracciano,Joseph Terracciano,Mahesh Patel,Vincent P. Gullo,Nicole Wagner,Bahige M. Baroudy,Mohindar S. Puar,Tze-Ming Chan,Min Chu +10 more
TL;DR: A novel fungal secondary metabolite, Sch 213766 was isolated from the fungal fermentation broth of Chaetomium globosum as the chemokine receptor CCR-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid Sch 210972 on the basis of UV, MS and NMR spectral data analyses.