Nicole Steinbach
Icahn School of Medicine at Mount Sinai
6 Papers
Nicole Steinbach is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: PTEN & PI3K/AKT/mTOR pathway. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Nicole Steinbach include Columbia University Medical Center & Columbia University.
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Papers
A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Benjamin D. Hopkins,Barry Fine,Nicole Steinbach,Nicole Steinbach,Meaghan Dendy,Zachary Rapp,Jacquelyn Shaw,Jacquelyn Shaw,Kyrie Pappas,Kyrie Pappas,Jennifer S. Yu,Cindy Hodakoski,Sarah M. Mense,Joshua U. Klein,Joshua U. Klein,Sarah Pegno,Maria Luisa Sulis,Maria Luisa Sulis,Hannah E. Goldstein,Hannah E. Goldstein,Benjamin Amendolara,Benjamin Amendolara,Liang Lei,Liang Lei,Matthew Maurer,Matthew Maurer,Jeffrey N. Bruce,Peter Canoll,Peter Canoll,Hanina Hibshoosh,Hanina Hibshoosh,Ramon Parsons +31 more
TL;DR: A 576–amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base pairs upstream of the ATG initiation sequence, adding 173 N-terminal amino acids to the normal PTEN open reading frame may have therapeutic uses.
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.
Deepti Mathur,Deepti Mathur,Elias E. Stratikopoulos,Sait Ozturk,Nicole Steinbach,Nicole Steinbach,Sarah Pegno,Sarah M. Schoenfeld,Raymund Yong,Vundavalli V. Murty,John M. Asara,Lewis C. Cantley,Ramon Parsons +12 more
TL;DR: This work has found a prospective targeted therapy for PTEN-deficient tumors, with efficacy in vitro and in vivo in tumors derived from different tissues, based upon the changes in glutamine metabolism, DNA replication, and DNA damage response which are consequences of inactivation of PTENCancer Discov.
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
Sarah M. Mense,Douglas Barrows,Douglas Barrows,Cindy Hodakoski,Nicole Steinbach,Nicole Steinbach,David Schoenfeld,David Schoenfeld,William Su,Benjamin D. Hopkins,Tao Su,Barry Fine,Hanina Hibshoosh,Ramon Parsons +13 more
TL;DR: It is shown that PTEN suppresses cell migration and invasion by blocking PREX2 activity, and PREx2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion.
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p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes
Kyrie Pappas,Kyrie Pappas,Jia Xu,Sakellarios Zairis,Lois Resnick-Silverman,Francesco Abate,Nicole Steinbach,Nicole Steinbach,Sait Ozturk,Lao H. Saal,Tao Su,Pamela Cheung,Hank Schmidt,Hank Schmidt,Stuart A. Aaronson,Hanina Hibshoosh,James J. Manfredi,Raul Rabadan,Ramon Parsons +18 more
TL;DR: It is found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters.
PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription
Nicole Steinbach,Dan Hasson,Deepti Mathur,Elias E. Stratikopoulos,Ravi Sachidanandam,Emily Bernstein,Ramon Parsons +6 more
TL;DR: The work describes a previously unappreciated role of nuclear PTEN, which by interacting with the transcription machinery in the context of chromatin exerts an additional layer of regulatory control on RNAPII-mediated transcription.