Confocal microscopes unlike their conventional counterparts have the ability to optically ‘section’ thick specimens. However the resolution and optical sectioning can be severely degraded by system or specimen-induced aberrations. The use of high aperture lenses further exacerbates the difficulties. We will describe an adaptive optics solution to this fundamental problem.

Adaptive optics in microscopy

United States. Dept. of Defense. Assistant Secretary of Defense for Research & Engineering (Air Force contract #FA8721-05-C-002)

/pdf/optical-design-and-characterization-of-an-advanced-58zkd9rw5n.pdf

Optical design and characterization of an advanced computational imaging system

We demonstrate a new versatile method for 3D super-resolution microscopy by using a deformable mirror to shape the point spread function of our microscope in a continuous and controllable way. We apply this for 3D STORM imaging of microtubules.

Improved 3D Superresolution Localization Microscopy Using Adaptive Optics

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Improved 3D Superresolution Localization Microscopy Using Adaptive Optics