Nicolas Papadopoulos
Ludwig Institute for Cancer Research
17 Papers
2 Citations
Nicolas Papadopoulos is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 3 publications. Previous affiliations of Nicolas Papadopoulos include Université catholique de Louvain.
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Papers
Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms.
Christian Pecquet,Nicolas Papadopoulos,Thomas Balligand,Ilyas Chachoua,Amandine Tisserand,Gaëlle Vertenoeil,Audrey Nédélec,Didier Vertommen,Anita Roy,Caroline Marty,Harini Nivarthi,Jean-Philippe Defour,Mira El-Khoury,Eva Hug,Andrea Majoros,Erica Xu,Oleh Zagrijtschuk,Tudor Emanuel Fertig,Daciana S. Marta,Heinz Gisslinger,Bettina Gisslinger,Martin Schalling,Ilaria Carola Casetti,Elisa Rumi,Daniela Pietra,Chiara Cavalloni,Luca Arcaini,Mario Cazzola,Norio Komatsu,Yoshihiko Kihara,Yoshitaka Sunami,Yoko Edahiro,Marito Araki,Roman Lesyk,Veronika Buxhofer-Ausch,Sonja Heibl,Florence Pasquier,Isabelle Plo,William Vainchenker,Robert Kralovics,Stefan N. Constantinescu +40 more
TL;DR: In this article , mutant calreticulin (CALR) proteins resulting from a -1/-2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino acid sequence and drive the development of myeloproliferative neoplasms (MPNs).
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Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
Florian Perrin,Florian Perrin,Nicolas Papadopoulos,Nicolas Papadopoulos,Nuria Suelves,Rémi Opsomer,Devkee M. Vadukul,Céline Vrancx,Steven O. Smith,Didier Vertommen,Pascal Kienlen-Campard,Stefan N. Constantinescu,Stefan N. Constantinescu +12 more
TL;DR: Crossing angles imposed by precise dimeric orientations control γ-secretase initial cleavage at Aβ48 or Aβ49, linking the former to enhanced signaling and Aβ42 production.
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Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation
Nicolas Papadopoulos,Audrey Nédélec,Allison Derenne,Teodor Asvadur Şulea,Christian Pecquet,Ilyas Chachoua,Gaëlle Vertenoeil,Thomas Tilmant,Andrei J. Petrescu,Gabriel Mazzucchelli,Bogdan I. Iorga,Didier Vertommen,Stefan N. Constantinescu +12 more
TL;DR: In this paper , the authors identify the basis of the acquired specificity of CALR mutants for TpoR and define the mechanisms by which complex formation triggers TPOR dimerization and activation.
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Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates
Nicolas Papadopoulos,Nuria Suelves,Florian Perrin,Devkee M. Vadukul,Celine Vrancx,Serban Constantinescu,Pascal Kienlen-Campard +6 more
TL;DR: In this article , the same motifs can control APP function and Aβ production essentially by regulating membrane protein dimerization, and subsequently Aβ aggregation processes, and the distinct properties of these motifs and the cellular context regulate the APP conformation to trigger the transition to the amyloid pathology.
Modulation of Human Thrombopoietin Receptor Conformations Uncouples JAK2 V617F-Driven From Cytokine-Induced Activation.
Nicolas Papadopoulos,Ajda Pristavec,Audrey Nédélec,Gabriel Levy,Judith Staerk,Stefan N. Constantinescu +5 more
TL;DR: Modulation of hTpoR conformation is demonstrated to be a viable therapeutic strategy for JAK2 V617F positive MPNs and set the path for novel drug development by identifying precise residues of h TpoR involved in JAK1 V617f specific activation.
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