Nicolas Melin
Novartis
5 Papers
Nicolas Melin is an academic researcher from Novartis. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 3 publications.
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Papers
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.
Dominic Hoepfner,Stephen B. Helliwell,Heather Sadlish,Sven Schuierer,Ireos Filipuzzi,Sophie Brachat,Bhupinder Bhullar,Uwe Plikat,Yann Abraham,Marc Altorfer,Thomas Aust,Lukas Baeriswyl,Raffaele Cerino,Lena Chang,David Estoppey,Juerg Eichenberger,Mathias Frederiksen,Nicole Hartmann,Annika Hohendahl,Britta Knapp,Philipp Krastel,Nicolas Melin,Florian Nigsch,Edward J. Oakeley,Virginie Petitjean,Frank Petersen,Ralph Riedl,Esther K. Schmitt,Frank Staedtler,Christian Studer,John A. Tallarico,Stefan Wetzel,Mark C. Fishman,Jeffrey A. Porter,N. Rao Movva +34 more
TL;DR: Using an optimized platform, the relative sensitivities of the heterozygous and homozygous deletion collections for nearly 1800 biologically active compounds are provided, providing unique insights into pathways that are sensitive and resistant to a given perturbation.
168
Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.
Tina Junne,Joanne Wong,Christian Studer,Thomas Aust,Benedikt W. Bauer,Martin Beibel,Bhupinder Bhullar,Robert Bruccoleri,Jürg Eichenberger,David Estoppey,Nicole Hartmann,Britta Knapp,Philipp Krastel,Nicolas Melin,Edward J. Oakeley,Lukas Oberer,Ralph Riedl,Guglielmo Roma,Sven Schuierer,Frank Petersen,John A. Tallarico,Tom A. Rapoport,Martin Spiess,Dominic Hoepfner,Dominic Hoepfner +24 more
TL;DR: Biochemical analysis confirmed inhibition of protein translocation into the endoplasmic reticulum of both co- and post-translationally translocated substrates by both chemotypes, demonstrating a mechanism independent of a translating ribosome.
69
A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus
Nicolas Melin,Tural Yarahmadov,Daniel Sánchez-Taltavull,Fabienne Birrer,Tess M. Brodie,Benoit Petit,Andrea Felser,Jean-Marc Nuoffer,M. Montani,Marie-Catherine Vozenin,Eva Herrmann,Daniel Candinas,Daniel M. Aebersold,Deborah Stroka +13 more
TL;DR: In this paper , a mouse model of radiation-induced liver fibrosis was established to investigate the underlying mechanism of radiationinduced liver disease (RILD), which is characterized by fibrosis of the pericentral sinusoids.
14
Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology:
Svenja Ley,Olaf Galuba,Adrian Salathe,Nicolas Melin,Alexandra Aebi,Monika Pikiolek,Judith Knehr,Walter Carbone,Martin Beibel,Florian Nigsch,Guglielmo Roma,Giovanni d'Ario,Susan Kirkland,Laure C. Bouchez,Caroline Gubser Keller,Tewis Bouwmeester,Christian N. Parker,Heinz Ruffner +17 more
- 06 Jan 2017
TL;DR: The assay was used to identify bioactive compounds, which served as probes to interrogate the biology of crypt organoids over prolonged culture, and the pathways that are changing over time may offer potential targets for treatment of mucositis.
14
Intracellular Proprotein convertase subtilisin/kexin type 9: Recruitment and regulatory role in mitochondrial architecture and bioenergetic
Jacopo Gavini,D. Leuenberger,Tural Yarahmadov,Noelle Dommann,Adrian Keogh,Nicolas Melin,Mario P. Tschan,Jean-Marc Nuoffer,Damian Hertig,Benoît Zuber,Adolfo Odriozola,Riccardo Tombolini,Michel Chrétien,Majambu Mbikay,Daniel Candinas,Deborah Stroka +15 more
TL;DR: A novel intracellular function of PCSK9 is described in hepatocyte metabolism and in liver regeneration and its impact on mitochondrial architecture, membrane polarization and related metabolic perturbations in compartmental bioenergetics is shed.