Nicolas Hulo
University of Geneva
50 Papers
90 Citations
Nicolas Hulo is an academic researcher from University of Geneva. The author has contributed to research in topics: PROSITE & Biology. The author has an hindex of 27, co-authored 40 publications. Previous affiliations of Nicolas Hulo include Swiss Institute of Bioinformatics & European Bioinformatics Institute.
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Papers
InterPro: the integrative protein signature database
Sarah Hunter,Rolf Apweiler,Teresa K. Attwood,Amos Marc Bairoch,Alex Bateman,David Binns,Peer Bork,Ujjwal Das,Louise C. Daugherty,Lauranne Duquenne,Robert D. Finn,Julian Gough,Daniel H. Haft,Nicolas Hulo,Daniel Kahn,Elizabeth Kelly,Aurélie Laugraud,Ivica Letunic,David M. Lonsdale,Rodrigo Lopez,Martin Madera,John Maslen,Craig McAnulla,Jennifer McDowall,Jaina Mistry,Alex L. Mitchell,Nicola Mulder,Darren A. Natale,Christine A. Orengo,Antony F. Quinn,Jeremy D. Selengut,Christian J. A. Sigrist,Manjula Thimma,Paul Thomas,Franck Valentin,Derek Wilson,Cathy H. Wu,Corin Yeats +37 more
TL;DR: The InterPro database integrates together predictive models or ‘signatures’ representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs.
ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins
Edouard de Castro,Christian J. A. Sigrist,Alexandre Gattiker,Virginie Bulliard,Petra S. Langendijk-Genevaux,Elisabeth Gasteiger,Amos Marc Bairoch,Nicolas Hulo +7 more
TL;DR: A new and improved version of the web-based tool for detecting PROSITE signature matches in protein sequences that makes use of ProRules—context-dependent annotation templates—to detect functional and structural intra-domain residues.
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New and continuing developments at PROSITE
Christian J. A. Sigrist,Edouard de Castro,Lorenzo Cerutti,Béatrice A. Cuche,Nicolas Hulo,Alan Bridge,Lydie Bougueleret,Ioannis Xenarios +7 more
TL;DR: Recent developments that allow users to perform whole-proteome annotation as well as a number of filtering options that can be combined to perform powerful targeted searches for biological discovery are described.
The InterPro database, an integrated documentation resource for protein families, domains and functional sites
Rolf Apweiler,Teresa K. Attwood,Amos Marc Bairoch,Alex Bateman,Ewan Birney,Margaret Biswas,Philipp Bucher,Lorenzo Cerutti,Florence Corpet,Michael D. R. Croning,Richard Durbin,Laurent Falquet,Wolfgang Fleischmann,Jérôme Gouzy,Henning Hermjakob,Nicolas Hulo,Inge Jonassen,Daniel Kahn,Alexander Kanapin,Youla Karavidopoulou,Rodrigo Lopez,Beate Marx,Nicola Mulder,Tom Oinn,Marco Pagni,Florence Servant,Christian J. A. Sigrist,Evgeni M. Zdobnov +27 more
TL;DR: InterPro is an integrated documentation resource for protein families, domains and functional sites, which amalgamates the efforts of the PROSITE, PRINTS, Pfam and ProDom database projects.
The PROSITE database
Nicolas Hulo,Amos Marc Bairoch,Virginie Bulliard,Lorenzo Cerutti,Edouard de Castro,Petra S. Langendijk-Genevaux,Marco Pagni,Christian J. A. Sigrist +7 more
TL;DR: The PROSITE database consists of a large collection of biologically meaningful signatures that are described as patterns or profiles that provides useful biological information on the protein family, domain or functional site identified by the signature.