Nicolas Aznar
University of California, San Diego
36 Papers
106 Citations
Nicolas Aznar is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Wnt signaling pathway & Heterotrimeric G protein. The author has an hindex of 13, co-authored 31 publications. Previous affiliations of Nicolas Aznar include University of Lyon & University of California, Los Angeles.
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Papers
Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin
Changsheng Lin,Jason Ear,Krishna Midde,Inmaculada Lopez-Sanchez,Nicolas Aznar,Mikel Garcia-Marcos,Irina Kufareva,Ruben Abagyan,Pradipta Ghosh +8 more
TL;DR: GIV, a guanidine exchange factor for trimeric Gi, contains a unique domain that functions like a SH2 domain that binds autophosphorylated RTKs and abolition of GIV:RTK interaction abolishes GIV-dependent Akt enhancement downstream ofRTKs.
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Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time
TL;DR: This work provides the most complete up‐to‐date review of the molecular mechanisms that govern the unique spatiotemporal aspects of non‐canonical G protein activation by GIV and the relevance of this new paradigm in health and disease.
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Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.
Krishna Midde,Nicolas Aznar,Melanie B. Laederich,Gary S. Ma,Maya T. Kunkel,Alexandra C. Newton,Pradipta Ghosh +6 more
TL;DR: Modular fluorescent biosensors that exploit the remarkable specificity of bimolecular recognition are developed that provide direct evidence that RTK–GIV–Gαi ternary complexes are formed in living cells and that Gαi is transactivated within minutes after growth factor stimulation at the plasma membrane.
Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.
Hélène Gaude,Nicolas Aznar,Delay A,Bres A,Karine Buchet-Poyau,Christophe Caillat,Armelle Vigouroux,Christian Rogon,Woods A,Jean-Marc Vanacker,Jörg Höhfeld,Christine Perret,Philippe Meyer,Marc Billaud,Forcet C +14 more
TL;DR: This study shows that two chaperone complexes with antagonizing activities, Hsp90–Cdc37 and Hsp/Hsc70–CHIP, finely control the cellular level of LKB1 protein.
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The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated
Roumaïssa Gouasmi,Carole Ferraro-Peyret,Stéphane Nancey,Isabelle Coste,Toufic Renno,Cédric Chaveroux,Nicolas Aznar,Stéphane Ansieau +7 more
TL;DR: An overview of the current knowledge about the kynurenine pathway is given, to point out the next challenges, and to propose alternative therapeutic routes to achieve medical success.