Nicola La Monica
Merck & Co.
83 Papers
1.6K Citations
Nicola La Monica is an academic researcher from Merck & Co.. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 38, co-authored 83 publications. Previous affiliations of Nicola La Monica include Schering-Plough & ARIAD Pharmaceuticals, Inc..
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Papers
Enhancing B- and T-Cell Immune Response to a Hepatitis C Virus E2 DNA Vaccine by Intramuscular Electrical Gene Transfer
Silvia Zucchelli,Stefania Capone,Elena Fattori,Antonella Folgori,Annalise Di Marco,Danilo R. Casimiro,Adam J. Simon,Ralph Laufer,Nicola La Monica,Riccardo Cortese,Alfredo Nicosia +10 more
TL;DR: An improved genetic immunization strategy for eliciting a full spectrum of anti-hepatitis C virus (HCV) envelope 2 (E2) glycoprotein responses in mammals through electrical gene transfer (EGT) of plasmid DNA into muscle fibers potentially provides a safe, low-cost treatment that may be scaled up to humans.
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Site-Specific Integration in Mammalian Cells Mediated by a New Hybrid Baculovirus–Adeno-Associated Virus Vector
Fabio Palombo,Andrea Monciotti,Alessandra Recchia,Riccardo Cortese,Gennaro Ciliberto,Nicola La Monica +5 more
TL;DR: New hybrid vectors which associate key elements from adeno-associated virus (AAV) with the elevated transducing capacity of baculovirus indicate that Bac-AAV hybrid vectors can allow permanent, nontoxic gene delivery of DNA constructs for ex vivo treatment of primary human cells.
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Baculovirus Vectors Elicit Antigen-Specific Immune Responses in Mice
TL;DR: Both vectors elicited CD8+ T cells with effector function capable of lysing target cells loaded with a hepatitis C virus-specific epitope and further demonstrate that baculovirus may be considered a useful vector for gene therapy.
111
Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.
Elisabetta Pizzi,Anna Tramontano,Licia Tomei,Nicola La Monica,Cristina Maria Failla,Mohinder K. Sardana,Theresa Wood,Raffaele De Francesco +7 more
TL;DR: A model of the specificity pocket of the protease of hepatitis C virus is built on the basis of the known structures of trypsin-like serine proteases and of the conservation patterns among various hepatitis C strains to predict that the substrate of this protease should have a cysteine residue in position P1.
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Gene electrotransfer results in a high-level transduction of rat skeletal muscle and corrects anemia of renal failure
Gabriella Rizzuto,Manuela Cappelletti,Carmela Mennuni,Maciej Wiznerowicz,Anna Demartis,Domenico Maione,Gennaro Ciliberto,Nicola La Monica,Elena Fattori +8 more
TL;DR: Results demonstrate that gene electrotransfer can be applied to produce therapeutically significant levels of erythropoietin in chronic renal failure.
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