Nicholas Van Sciver
University of Wisconsin-Madison
7 Papers
10 Citations
Nicholas Van Sciver is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Lytic cycle & Epstein–Barr virus. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Nicholas Van Sciver include Worcester Polytechnic Institute.
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Papers
B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection.
James C. Romero-Masters,Shane M. Huebner,Makoto Ohashi,Jillian A. Bristol,Bayleigh E. Benner,Elizabeth A. Barlow,Gail L. Turk,Scott E. Nelson,Dana C. Baiu,Nicholas Van Sciver,Erik A. Ranheim,Jenny E. Gumperz,Nathan M. Sherer,Paul J. Farrell,Eric Johannsen,Shannon C. Kenney +15 more
TL;DR: B cells infected with T2 EBV are more lytic due to increased activity of the cellular NFATc1/c2 transcription factors in addition to the universal presence of the Zp-V3 form of BZLF1 promoter.
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Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle.
Mark R. Eichelberg,Rene Welch,J. Tod Guidry,Ahmed Ali,Makoto Ohashi,Kathleen R. Makielski,Kyle G. McChesney,Nicholas Van Sciver,Paul F. Lambert,Sündüz Keleș,Shannon C. Kenney,Rona S. Scott,Eric Johannsen +12 more
TL;DR: The results help to define the mechanisms by which EBV infection alters keratinocyte differentiation and provide a basis for understanding the role of EBV in epithelial cancers.
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EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice
Chunrong Li,James C. Romero-Masters,Shane M. Huebner,Makoto Ohashi,Mitchell Hayes,Jillian A. Bristol,Scott E. Nelson,Mark R. Eichelberg,Nicholas Van Sciver,Erik A. Ranheim,Rona S. Scott,Eric Johannsen,Shannon C. Kenney +12 more
TL;DR: It is shown that a naturally occurring EBNA2-deleted EBV strain (P3HR1) isolated from a human BL induces EBV-positive B-cell lymphomas in a subset of infected cord blood-humanized (CBH) mice and suggests that P3 HR1 virus can be used to model EBV positive lymphomas with both Wp-restricted and type II latency in vivo.
Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells.
Nicholas Van Sciver,Makoto Ohashi,Nicholas P. Pauly,Jillian A. Bristol,Scott E. Nelson,Eric Johannsen,Shannon C. Kenney +6 more
TL;DR: In this paper, the Hippo signaling effectors, YAP and TAZ, promote lytic EBV reactivation in epithelial cells, and they are shown to be powerful inducers of the lytic form of EBV infection and suggest that the ability of the EBV to enter latency in B cells at least partially reflects the extremely low levels of YAP/TAZ and TEADs in this cell type.
Human Cytomegalovirus Productively Replicates In Vitro in Undifferentiated Oral Epithelial Cells.
Chao Weng,Denis Lee,Christopher B. Gelbmann,Nicholas Van Sciver,Dhananjay M. Nawandar,Shannon C. Kenney,Robert F. Kalejta +6 more
TL;DR: It is discovered that HCMV productively replicates in normal oral keratinocytes and telomerase-immortalized gingival cells (hGETs), which introduces oral epithelial cells for the study of H CMV productive infection, drug screening, and vaccine development.
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