Nicholas Stone
Georgia Institute of Technology
12 Papers
11 Citations
Nicholas Stone is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Cell sorting & Induced pluripotent stem cell. The author has an hindex of 4, co-authored 7 publications.
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Papers
Microfluidic Sorting of Cells by Viability Based on Differences in Cell Stiffness
Muhymin Islam,Hannah Brink,Syndey Blanche,Caleb DiPrete,Tom Bongiorno,Nicholas Stone,Anna Liu,Anisha Philip,Gonghao Wang,Wilbur A. Lam,Wilbur A. Lam,Alexander Alexeev,Edmund K. Waller,Todd Sulchek +13 more
TL;DR: A label-free microfluidic technique to separate live and dead cells that exploits differences in cellular stiffness can simply and efficiently obtain highly pure populations of viable cells.
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Microfluidic generation of transient cell volume exchange for convectively driven intracellular delivery of large macromolecules
Anna Liu,Muhymin Islam,Nicholas Stone,Vikram Varadarajan,Jenny Jeong,Samuel Bowie,Peng Qiu,Edmund K. Waller,Alexander Alexeev,Todd Sulchek +9 more
TL;DR: A unique cell biophysical phenomenon of transient cell volume exchange is discovered by using microfluidics to rapidly and repeatedly compress cells and has potential to overcome the most prohibitive challenges in intracellular delivery for cell engineering.
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Microfluidic Platform to Transduce Cell Viability to Distinct Flow Pathways for High-Accuracy Sensing
Fatima Ezahra Chrit,A. Raj,Katherine M. Young,Nicholas Stone,Peter G. Shankles,Kesiharjun Lokireddy,Christopher R. Flowers,Edmund K. Waller,Alexander Alexeev,Todd Sulchek +9 more
TL;DR: In this paper, the authors used a microfluidic device as a high-sensitivity sensor that transduces cell biomechanics to cell separation to accurately detect viability, where cell populations are flowed and deflected at a number of skew ridges.
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Label-free microfluidic enrichment of cancer cells from non-cancer cells in ascites.
Nicholas Stone,A. Raj,Katherine M. Young,Adam P. DeLuca,Fatima Ezahra Chrit,Budd A. Tucker,Alexander Alexeev,John F. McDonald,Benedict B. Benigno,Todd Sulchek +9 more
TL;DR: In this article, a microfluidic platform capable of label-free enrichment of tumor cells from the ascites fluid of ovarian cancer patients is presented. But the method is not suitable for the case when specific surface markers do not exist for cells of interest.
Microfluidic processing of stem cells for autologous cell replacement.
TL;DR: In this article, a review of the literature pertaining to the use of different cell sorting and transfection approaches with a focus on the development and use of novel next generation microfluidic devices is presented.
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