Nicholas Pulliam
Indiana University
11 Papers
48 Citations
Nicholas Pulliam is an academic researcher from Indiana University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 6, co-authored 9 publications.
Chat about Author
Papers
An Effective Epigenetic-PARP Inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA Mutations.
Nicholas Pulliam,Fang Fang,Ali R. Özeş,Jessica Tang,Adeoluwa Adewuyi,Harold N. Keer,John Lyons,Stephen B. Baylin,Daniela Matei,Harikrishna Nakshatri,Feyruz V. Rassool,Kathy D. Miller,Kenneth P. Nephew +12 more
TL;DR: The novel combination of the next-generation DNMTi guadecitabine and the first-in-class PARPi talazoparib inhibited breast and ovarian cancers harboring either wild-type– or mutant-BRCA, supporting further clinical exploration of this drug combination in PARPi-resistant cancers.
Functional characterization of a panel of high-grade serous ovarian cancer cell lines as representative experimental models of the disease.
James Haley,Sunil Tomar,Nicholas Pulliam,Sen Xiong,Susan M. Perkins,Adam R. Karpf,Sumegha Mitra,Kenneth P. Nephew,Anirban K. Mitra +8 more
- 31 May 2016
TL;DR: Mitra et al. as discussed by the authors systematically studied a panel of high grade serous ovarian cancer (HGSOC) cells for migration, invasion, proliferation, clonogenicity, EMT phenotype and cisplatin resistance.
31
Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity.
Ali R. Özeş,Nicholas Pulliam,Mustafa Gökhan Ertosun,Ozlem Yilmaz,Jessica Tang,Ece Çopuroğlu,Daniela Matei,Osman Nidai Ozes,Kenneth P. Nephew +8 more
TL;DR: It is demonstrated that PKA-mediated T372 phosphorylation reduces oncogenic EZH2 activity and reveal a novel role for pT372 in regulating EZh2 in OC and possibly other cancers.
Epigenetic Targeting of Adipocytes Inhibits High-Grade Serous Ovarian Cancer Cell Migration and Invasion.
Jessica Tang,Nicholas Pulliam,Ali R. Özeş,Aaron Buechlein,Ning Ding,Harold N. Keer,Doug Rusch,Heather M. O'Hagan,M. Sharon Stack,Kenneth P. Nephew +9 more
TL;DR: The effect of DNMT inhibitor on fully differentiated adipocytes suggests that hypomethylating agents may affect the tumor microenvironment to decrease cancer cell metastasis.
Epigenetic Targeting of Adipocytes Inhibits High-Grade Serous Ovarian Cancer Cell Migration and Invasion
Jessica Tang,Nicholas Pulliam,Ali R. Özeş,Aaron Buechlein,Ning Ding,Harold N. Keer,Doug Rusch,Heather M. O'Hagan,M. Sharon Stack,Kenneth P. Nephew +9 more
- 01 Aug 2018
TL;DR: In this article, the authors examined the effect of adipocytes on ovarian cancer cell behavior in culture and the impact of targeting DNA methylation in adipocyte on ovarian tumor metastasis.
9