Nicholas I. Carruthers
Johnson & Johnson Pharmaceutical Research and Development
67 Papers
611 Citations
Nicholas I. Carruthers is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Histamine H3 receptor & Histamine. The author has an hindex of 29, co-authored 66 publications. Previous affiliations of Nicholas I. Carruthers include Johnson & Johnson & Binghamton University.
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Papers
Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat
Christine Dugovic,Jonathan Shelton,Leah Aluisio,Ian Fraser,Xiaohui Jiang,Steven W. Sutton,Pascal Bonaventure,Sujin Yun,Xiaorong Li,Brian Lord,Curt A. Dvorak,Nicholas I. Carruthers,Timothy W. Lovenberg +12 more
TL;DR: Results indicate that blockade of OX2R is sufficient to initiate and prolong sleep, consistent with the hypothesis of a deactivation of the histaminergic system.
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Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement.
James R. Shoblock,Natalie Welty,Leah Aluisio,Ian Fraser,S. Timothy Motley,Kirsten L. Morton,James A. Palmer,Pascal Bonaventure,Nicholas I. Carruthers,Timothy W. Lovenberg,Jamin D. Boggs,Ruggero Galici,Ruggero Galici +12 more
TL;DR: Results indicate, for the first time, that blockade of orexin-2 receptors is effective in reducing the reinforcing effects of ethanol.
159
Histamine H3 receptor antagonists: from target identification to drug leads
Pascal Bonaventure,Michael A. Letavic,Christine Dugovic,Sandy J. Wilson,Leah Aluisio,Cindy Pudiak,Brian Lord,Curt Mazur,Fredrik Kamme,S. Nishino,Nicholas I. Carruthers,Timothy W. Lovenberg +11 more
TL;DR: In vivo pharmacological evaluation showed that H(3) antagonists promote wakefulness, but unlike modafinil and classical psychostimultants, they do not increase locomotor activity or produce any alteration of the EEG power spectral activity in rats.
142
Non-imidazole heterocyclic histamine H3 receptor antagonists.
Wenying Chai,J. Guy Breitenbucher,Annette K. Kwok,Xiaobing Li,Victoria D. Wong,Nicholas I. Carruthers,Timothy W. Lovenberg,Curt Mazur,Sandy J. Wilson,Frank U. Axe,Todd K. Jones +10 more
TL;DR: The synthesis and SAR of indolizine, indole and pyrazolopyridine based compounds are described and several related series of heterocyclic histamine H(3) antagonists are discovered.
109
Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling
Scott D. Bembenek,John M. Keith,Michael A. Letavic,Richard Apodaca,Ann J. Barbier,Lisa Dvorak,Leah Aluisio,Kirsten L. Miller,Timothy W. Lovenberg,Nicholas I. Carruthers +9 more
TL;DR: Here, the use of the available crystal structure information, pharmacophore modeling and docking lead to the identification of an AChE inhibitor-histamine H(3) receptor antagonist, which may be able to affect the pathology of AD in addition to providing symptomatic relief.
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