Nicholas Hamilton
University College London
27 Papers
68 Citations
Nicholas Hamilton is an academic researcher from University College London. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 11, co-authored 27 publications. Previous affiliations of Nicholas Hamilton include Guy's Hospital & UCL Ear Institute.
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Papers
Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering
Colin R. Butler,Robert E. Hynds,Kate H.C. Gowers,Dani Do Hyang Lee,James Brown,Claire Crowley,Vitor H. Teixeira,Claire Smith,Luca Urbani,Nicholas Hamilton,Ricky Thakrar,Helen Booth,Martin A. Birchall,Paolo De Coppi,Adam Giangreco,Christopher O'Callaghan,Sam M. Janes +16 more
TL;DR: The authors' method generates large numbers of functional airway basal epithelial cells with the efficiency demanded by clinical transplantation, suggesting its suitability for use in tracheal reconstruction.
Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study
Nicholas Hamilton,Mazyar Kanani,Derek J. Roebuck,Richard Hewitt,Raul Cetto,Emily J. Culme-Seymour,Ed C. Toll,Alister J. Bates,A. Comerford,Clare A. McLaren,Colin R. Butler,C. Crowley,Denise McIntyre,Neil J. Sebire,Sam M. Janes,Christopher O'Callaghan,Christopher E. Mason,P De Coppi,Mark W. Lowdell,Martin J. Elliott,Martin A. Birchall +20 more
TL;DR: The long‐term viability of a decellularized tissue‐engineered trachea within a child is demonstrated and further research is needed to develop bioengineered pediatric tracheal replacements with lower morbidity, better biomechanics and lower costs.
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Tracheal Replacement Therapy with a Stem Cell‐Seeded Graft: Lessons from Compassionate Use Application of a GMP‐Compliant Tissue‐Engineered Medicine
Martin Elliott,Colin R. Butler,Colin R. Butler,Aikaterini Varanou-Jenkins,Leanne Partington,Carla Carvalho,Edward R. Samuel,Claire Crowley,Peggy Lange,Nicholas Hamilton,Robert E. Hynds,Tahera Ansari,Paul Sibbons,Anja Fierens,Claire McLaren,Derek J. Roebuck,C Wallis,Nagarajan Muthialu,Richard Hewitt,David Crabbe,Sam M. Janes,Paolo De Coppi,Mark W. Lowdell,Martin A. Birchall +23 more
TL;DR: An acute event, hypothesized to be an intrathoracic bleed, caused sudden airway obstruction 3 weeks post‐transplantation, resulting in the death of the recipient, and the practical difficulties in delivering GMP grafts underscore the need to refine protocols for phase I clinical trials.
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LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development
L Lu,Vitor H. Teixeira,ZhengQiang Yuan,Trevor A. Graham,Trevor A. Graham,David Endesfelder,Krishna K. Kolluri,Noura Al-Juffali,Nicholas Hamilton,Andrew G. Nicholson,Mary Falzon,Maik Kschischo,Charles Swanton,Nicholas A. Wright,Nicholas A. Wright,Bernadette Carroll,Fiona M. Watt,Jeremy George,Kim B. Jensen,Adam Giangreco,Sam M. Janes +20 more
TL;DR: It is found that deletion of Lrig1 is sufficient to promote murine airway hyperplasia through loss of contact inhibition and that re‐expression of LRIG1 in human lung cancer cells inhibits tumourigenesis, implying that the early stages of squamous carcinoma development are driven by a change in amplitude of EGFR signalling governed by the loss ofContact inhibition.
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Tissue engineering airway mucosa: A systematic review
TL;DR: A systematic review of the literature on tissue‐engineered airway mucosa to assess the success of this technology and its potential application to airway regenerative medicine and to determine the direction of future research to maximize its therapeutic and commercial potential.
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