Nicholas F. Totty
Ludwig Institute for Cancer Research
43 Papers
825 Citations
Nicholas F. Totty is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Peptide sequence & Biology. The author has an hindex of 33, co-authored 43 publications. Previous affiliations of Nicholas F. Totty include University of Basel & London Research Institute.
Chat about Author
Papers
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
TL;DR: The active components of purified ω1 are two proteins that associate as heterodimers17, and here it is reported that these are the small GTP-binding protein p21racl and the GDP-dissociation inhibitor rhoGDI.
996
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.
TL;DR: YAP overexpression increases, while YAP depletion decreases, p73-mediated apoptosis following DNA damage, in an Akt inhibitable manner, and Akt phosphorylation of YAP may thus suppress the induction of the proapoptotic gene expression response following cellular damage.
877
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.
Mark A. Marchionni,Andrew Goodearl,Maio Su Chen,Olivia Bermingham-McDonogh,Cassandra Kirk,Marvin Hendricks,Frank Danehy,Don Misumi,Judith Sudhalter,Kazumi Kobayashi,Diana Wroblewski,Catherine Lynch,Mark Baldassare,Ian Hiles,John B. Davis,John B. Davis,J. Justin Hsuan,Nicholas F. Totty,Masayuki Otsu,Robert N. McBurney,Michael D. Waterfield,Paul Stroobant,David I. Gwynne +22 more
TL;DR: Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain.
831
Phosphatidylinositol 3-kinase : structure and expression of the 110 kd catalytic subunit
Ian Hiles,Masayuki Otsu,Stefano Volinia,Michael J. Fry,Ivan Gout,Ritu Dhand,George Panayotou,Fernanda Ruiz-Larrea,Andrew J. Thompson,Nicholas F. Totty,J. Justin Hsuan,Sara A. Courtneidge,Peter J. Parker,Michael D. Waterfield,Michael D. Waterfield +14 more
TL;DR: The characterization of the p110 subunit of Purified bovine brain phosphatidylinositol 3-kinase reveals p110 to be a 1068 aa protein related to Vps34p, a S. cerevisiae protein involved in the sorting of proteins to the vacuole.
709
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif
L. Miguel Martins,Ingram Iaccarino,Tencho Tenev,Stephen Gschmeissner,Nicholas F. Totty,Nicholas R. Lemoine,John Savopoulos,Carol W. Gray,Caretha L. Creasy,Colin Dingwall,Julian Downward +10 more
TL;DR: The serine protease Omi/HtrA2 is identified as a second mammalian XIAP-binding protein with a Reaper-like motif, and this protease autoprocesses to form a protein with amino-terminal homology to Smac/DIABLO and Reaper family proteins.
599