Nicholas E. Vangos
Harvard University
10 Papers
16 Citations
Nicholas E. Vangos is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & PIN1. The author has an hindex of 5, co-authored 8 publications.
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Papers
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Christian Dubiella,Benika J. Pinch,Kazuhiro Koikawa,Kazuhiro Koikawa,Daniel Zaidman,Evon Poon,Theresa D. Manz,Theresa D. Manz,Behnam Nabet,Shuning He,Efrat Resnick,Adi Rogel,Ellen M. Langer,Colin J. Daniel,Hyuk-Soo Seo,Ying Chen,Guillaume Adelmant,Shabnam Sharifzadeh,Scott B. Ficarro,Yann Jamin,Barbara Martins da Costa,Mark W. Zimmerman,Xiaolan Lian,Xiaolan Lian,Shin Kibe,Shin Kibe,Shingo Kozono,Shingo Kozono,Zainab M. Doctor,Christopher M. Browne,Christopher M. Browne,Annan Yang,Liat Stoler-Barak,Richa B. Shah,Nicholas E. Vangos,Ezekiel A. Geffken,Roni Oren,Eriko Koide,Samuel Sidi,Ziv Shulman,Chu Wang,Jarrod A. Marto,Sirano Dhe-Paganon,Thomas Look,Thomas Look,Xiao Zhen Zhou,Xiao Zhen Zhou,Kun Ping Lu,Kun Ping Lu,Rosalie C. Sears,Louis Chesler,Nathanael S. Gray,Nathanael S. Gray,Nir London +53 more
TL;DR: Sulfopin this article, a nanomolar Pin1 inhibitor, was developed to identify covalent inhibitors targeting Pin1's active site Cys113, which achieved potent cellular and in vivo target engagement and phenocopies Pin1 genetic knockout.
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Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
Alfredo M. Valencia,Alfredo M. Valencia,Clayton K. Collings,Clayton K. Collings,Hai T. Dao,Roodolph St. Pierre,Roodolph St. Pierre,Yung-Chih Cheng,Yung-Chih Cheng,Junwei Huang,Junwei Huang,Zhen-Yu Sun,Hyuk-Soo Seo,Nazar Mashtalir,Nazar Mashtalir,Dawn E. Comstock,Dawn E. Comstock,Olubusayo Bolonduro,Olubusayo Bolonduro,Nicholas E. Vangos,Zoe C. Yeoh,Mary K. Dornon,Mary K. Dornon,Crystal Hermawan,Crystal Hermawan,Lee Barrett,Lee Barrett,Sirano Dhe-Paganon,Clifford J. Woolf,Clifford J. Woolf,Tom W. Muir,Cigall Kadoch,Cigall Kadoch +32 more
TL;DR: The studies unmask an evolutionarily conserved structural role for the SMARCB1 CTD that is perturbed in human disease, which results in dominant gene regulatory and morphologic changes during iPSC-neuronal differentiation.
95
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
Yusuke Fukuda,Maria F. Pazyra-Murphy,Elizabeth S. Silagi,Ozge E. Tasdemir-Yilmaz,Yihang Li,Lillian Rose,Zoe C. Yeoh,Nicholas E. Vangos,Ezekiel A. Geffken,Hyuk-Soo Seo,Guillaume Adelmant,Gregory H. Bird,Loren D. Walensky,Jarrod A. Marto,Sirano Dhe-Paganon,Rosalind A. Segal +15 more
TL;DR: It is demonstrated that the RNA-binding protein SFPQ is preferentially transported by KIF5A rather than other motors of the kinesin-1 family, which provides a mechanistic understanding of specificity for neurologic diseases linked to the Kif5A gene.
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Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growthin vivo
Christian Dubiella,Benika J. Pinch,Daniel Zaidman,Trevor Manz,Trevor Manz,Evon Poon,Shijie He,Efrat Resnick,Ellen M. Langer,Colin J. Daniel,Hyuk-Soo Seo,Yu-Hong Chen,Scott B. Ficarro,Yann Jamin,Xiaolan Lian,Xiaolan Lian,Shin Kibe,Shin Kibe,Shingo Kozono,Shingo Kozono,Kazuhiro Koikawa,Kazuhiro Koikawa,Zm,Behnam Nabet,Christopher M. Browne,Anli Yang,Liat Stoler-Barak,Richa B. Shah,Nicholas E. Vangos,Ezekiel A. Geffken,Roni Oren,Samuel Sidi,Ziv Shulman,Chunhui Wang,Jarrod A. Marto,Sirano Dhe-Paganon,Thomas Look,Thomas Look,Xiao Zhou,Xiao Zhou,Kun Ping Lu,Kun Ping Lu,Rosalie C. Sears,Louis Chesler,Nathaniel Gray,Nir London +45 more
TL;DR: Sulfopin is a suitable chemical probe for assessing Pin1-dependent pharmacology in cells and in vivo and indicates that Pin1 should be further investigated as a potential cancer target.
Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration
Yusuke Fukuda,Maria F. Pazyra-Murphy,Ozge E. Tasdemir-Yilmaz,Li Y,Lynda M. Rose,Zoe C. Yeoh,Nicholas E. Vangos,Ezekiel A. Geffken,Hyuk-Soo Seo,Guillaume Adelmant,Bird Gh,Loren D. Walensky,Jarrod A. Marto,Sirano Dhe-Paganon,Rosalind A. Segal +14 more
TL;DR: It is demonstrated that a complex containing RNA and the RNA-binding protein SFPQ interacts directly with a tetrameric kinesin containing the adaptor KLC1 and the motor KIF5A and that replacing axonally translated proteins provides a therapeutic approach to axonal degenerative disorders.