Nicholas Dillon
University of California, San Diego
29 Papers
41 Citations
Nicholas Dillon is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 10, co-authored 26 publications. Previous affiliations of Nicholas Dillon include University of Wisconsin-Madison & University of Montana.
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Papers
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
Seiya Kitamura,Qinheng Zheng,Jordan L. Woehl,Angelo Solania,Emily I. Chen,Nicholas Dillon,Mitchell V. Hull,Miyako Kotaniguchi,John R. Cappiello,Shinichi Kitamura,Victor Nizet,K. Barry Sharpless,Dennis W. Wolan +12 more
TL;DR: A high-throughput hit-to-lead process based on the biocompatible SuFEx click chemistry that succeeds on picomole scale for direct screening and can accelerate the development of robust biological probes and drug candidates is demonstrated.
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Uncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosis
TL;DR: It is found that unlike the bona fide ionophores monensin and carbonyl cyanide 3-chlorophenylhydrazone, PZA and POA do not induce rapid uncoupling or cytoplasmic acidification under conditions that promote susceptibility.
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The Bewildering Antitubercular Action of Pyrazinamide.
TL;DR: The four prevailing models for PZA action are discussed, recent developments in modulation of PZA susceptibility and resistance, and outlooks for future research and drug development are discussed.
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Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA.
TL;DR: It is demonstrated that M. tuberculosis RpsA interacts with single stranded RNA, but not with POA, and it is found that an interfering oligonucleotide can inhibit trans-translation, yet POA does not inhibitTrans-translation.
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Surprising synergy of dual translation inhibition vs. Acinetobacter baumannii and other multidrug-resistant bacterial pathogens.
Nicholas Dillon,Michelle Holland,Hannah Tsunemoto,Bryan Hancock,Ingrid Cornax,Joe Pogliano,George Sakoulas,George Sakoulas,Victor Nizet,Victor Nizet +9 more
TL;DR: An unexpected potent synergy of two translation inhibitors against the pathogen is shown, speeding the initiation and extending the duration of translation inhibition as verified by FICI, BCP and kinetic luminescence markers.
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