The invention relates to a pharmaceutical composition used for promoting skin healing. The pharmaceutical composition used for promoting the skin healing comprises a muscarinic receptor blocker and a cholinesterase inhibitor. After the pharmaceutical composition used for promoting the skin healing is applied to individuals (comprising human and animals) with a skin wound, newly born granulation tissues are thicker, collagen content is high, epidermis healing speed is high, no obvious toxic or side effect is produced, and no obvious influence is produced to diet, weight and hepatic and renal functions of a rat. The pharmaceutical composition provided by the invention can be used for well promoting the skin healing and produces no obvious toxic or side effect, so that the pharmaceutical composition used for promoting the skin healing has a good application prospect.

Pharmaceutical composition used for promoting skin healing and application thereof

Combined application of a cholinesterase inhibitor and a muscarinic receptor blocker is applied to preparation of a medicine for promoting liver regeneration after hepatectomy. After hepatectomy, the combination of the cholinesterase inhibitor and the muscarinic receptor blocker has obvious effects of promoting liver regeneration, minimizing swelling in hepatic lobule and reducing number of hepatic cells of vacuolar degeneration. Furthermore, recovery of liver function is promoted. In addition, the combination has no obvious toxic or side effect.

Combined application of cholinesterase inhibitor and muscarinic receptor blocker

The invention discloses a sustained-release tablet prepared by compounding anisodamine and neostigmine and a preparation method of the sustained-release tablet. The sustained-release tablet is prepared from the following components in parts by weight: 10-20 parts of the anisodamine, 0.01-1 part of the neostigmine, 5-50 parts of sustained-release matrix materials, 0.3-5 parts of a lubricant, 1-20 parts of an adhesive, 1-15 parts of a diluting agent, 1-50 parts of a disintegrating agents and 1-50 parts of a filling agent. The sustained-release tablet provided by the invention is smooth and steady in release; by taking the sustained-release tablet provided by the invention, dosing times are reduced, and cting time is increased; the compliance of a patient is improved; side effects caused by an overhigh peak concentrationh are lowered; the sustained-release tablet is simple in preparation process, relatively low in cost, easy to control and suitable for large-scale industrial production, and has relatively high application value.

Compound anisodamine and neostigmine sustained-release tablet and preparation method thereof

Disclosed herein are compositions for treating a subject with ischemia reperfusion injury or at risk of developing ischemia reperfusion injury, the method comprising administering to the subject an agonist of nicotinic cholinergic receptor α7nAchR. Also disclosed are methods and compositions for treating a subject with sepsis or at risk of developing an infection or sepsis, the method comprising administering to the subject an agonist of nicotinic cholinergic receptor α7nAchR. In one embodiment, the agonist of nicotinic cholinergic receptor α7nAchR is varenicline.

Methods and compositions for the prevention and treatment of ischemia reperfusion injury and infection

The invention discloses a preparation method of an ischemic preconditioning model. The preparation method comprises the following steps of: placing and fixing a small animal for preparing the model in a mouse cage, enabling the body of the small animal to be vertical to a spindle of a small animal centrifuge and enabling the head of the small animal to be towards the axis; starting a motor and enabling the motor to rotate for 5 minutes according to a preset speed; stopping the motor for 5 minutes; repeating the steps for three times at intervals of 24 hours and obtaining the ischemic preconditioning model after 72 hours. Correspondingly, the invention also provides the small animal centrifuge for the preparation method. By adopting the small animal centrifuge provided by the invention, the ischemic preconditioning model for research can be simply and effectively obtained on the premise of not damaging the small animal.

Ischemic preconditioning small animal centrifuge

Composition for resisting ischemia reperfusion injury and preparation method and application thereof

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Composition for resisting ischemia reperfusion injury and preparation method and application thereof