Nhu An Pham
Princess Margaret Cancer Centre
5 Papers
Nhu An Pham is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Carcinoma & Cancer. The author has an hindex of 4, co-authored 5 publications.
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Papers
Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer.
Ruoshi Shi,Ruoshi Shi,Nikolina Radulovich,Christine Ng,Ni Liu,Hirotsugu Notsuda,Michael Cabanero,Sebastiao N. Martins-Filho,Vibha Raghavan,Quan Li,Arvind Singh Mer,Joshua C. Rosen,Joshua C. Rosen,Ming Li,Yuhui Wang,Laura Tamblyn,Nhu An Pham,Benjamin Haibe-Kains,Geoffrey Liu,Geoffrey Liu,Nadeem Moghal,Nadeem Moghal,Ming-Sound Tsao,Ming-Sound Tsao +23 more
TL;DR: A panel of NSCLC organoids closely recapitulates the genomics and biology of patient tumors, and is a potential platform for drug testing and biomarker validation.
Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors
Dennis Wang,Dennis Wang,Nhu An Pham,Jiefei Tong,Shingo Sakashita,Ghassan Allo,Lucia Kim,Naoki Yanagawa,Vibha Raghavan,Yuhong Wei,Christine To,Quang M. Trinh,Maud H.W. Starmans,Michelle Chan-Seng-Yue,Dianne Chadwick,Lei Li,Chang-Qi Zhu,Ni Liu,Ming Li,Sharon Lee,Vladimir Ignatchenko,Dan Strumpf,Paul J. Taylor,Nadeem Moghal,Geoffrey Liu,Paul C. Boutros,Thomas Kislinger,Melania Pintilie,Igor Jurisica,Frances A. Shepherd,John Douglas Mcpherson,Lakshmi Muthuswamy,Michael F. Moran,Ming-Sound Tsao +33 more
TL;DR: The results provide the strongest evidence yet that PDXs established from lung cancers closely mimic the characteristics of patient primary tumors.
SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.
Bo Ram Kim,Bo Ram Kim,Emily Van de Laar,Michael Cabanero,Shintaro Tarumi,Stefan Hasenoeder,Dennis Wang,Carl Virtanen,Takaya Suzuki,Bizhan Bandarchi,Shingo Sakashita,Nhu An Pham,Sharon Lee,Shaf Keshavjee,Thomas K. Waddell,Ming-Sound Tsao,Ming-Sound Tsao,Nadeem Moghal,Nadeem Moghal +18 more
TL;DR: It is proposed that early pathogenesis of most SQCCs involves stabilization of the squamous injury state in stem cells through copy number gains at 3q, with the pro-proliferative activity of SOX9 possibly being exploited in a subset of SQ CCs in later stages.
Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma
Erin L. Stewart,Céline Mascaux,Nhu An Pham,Shingo Sakashita,Jenna Sykes,Lucia Kim,Naoki Yanagawa,Ghassan Allo,Kota Ishizawa,Dennis Wang,Chang-Qi Zhu,Ming Li,Christine Ng,Ni Liu,Melania Pintilie,Petra Martin,Thomas John,Igor Jurisica,Natasha B. Leighl,Benjamin G. Neel,Thomas K. Waddell,Frances A. Shepherd,Geoffrey Liu,Ming-Sound Tsao +23 more
TL;DR: PDX models closely recapitulate primary tumor biology and clinical outcome and may serve as important laboratory models to investigate mechanisms of resistance to targeted therapies, and for preclinical testing of novel treatment strategies.
CD45+CD326+ Cells are Predictive of Poor Prognosis in Non-Small Cell Lung Cancer Patients.
Kota Ishizawa,Mie Yamanaka,Yuriko Saiki,Eisaku Miyauchi,Shinichi Fukushige,Tetsuya Akaishi,Atsuko Asao,Takahiro Mimori,Ryota Saito,Yutaka Tojo,Riu Yamashita,Michiaki Abe,Akira Sakurada,Nhu An Pham,Ming Li,Yoshinori Okada,Tadashi Ishii,Naoto Ishii,Seiichi Kobayashi,Masao Nagasaki,Masakazu Ichinose,Ming-Sound Tsao,Ming-Sound Tsao,Akira Horii +23 more
TL;DR: Wang et al. as mentioned in this paper deployed a combination of cell surface markers to elucidate the phenotypic heterogeneity in non-small cell lung cancer (NSCLC) cells and identified a new subpopulation that is doubly-positive for epithelial and non-epithelial cell-surface markers in both NSCLC cells and patients9 malignant pleural effusions.