Ngoc H Pham
University of Wisconsin-Madison
6 Papers
12 Citations
Ngoc H Pham is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Major histocompatibility complex & Simian immunodeficiency virus. The author has an hindex of 5, co-authored 6 publications.
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Papers
Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques.
Melisa L. Budde,Justin M. Greene,Emily N. Chin,Adam J. Ericsen,Matthew Scarlotta,Brian T Cain,Ngoc H Pham,Ericka A. Becker,Max Harris,Jason T. Weinfurter,Shelby L. O’Connor,Michael Piatak,Jeffrey D. Lifson,Emma Gostick,David Price,Thomas C. Friedrich,David H. O’Connor +16 more
TL;DR: Results suggest that the T cell-mediated control of virus replication that is observed is more likely the consequence of targeting specificity rather than T cell breadth.
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Whole genome sequencing of SIV-infected macaques identifies candidate loci that may contribute to host control of virus replication
Adam J. Ericsen,Gabriel J. Starrett,Justin M. Greene,Michael Lauck,Muthuswamy Raveendran,David Rio Deiros,Mariel S. Mohns,Nicolas Vince,Nicolas Vince,Brian T Cain,Ngoc H Pham,Jason T. Weinfurter,Adam L. Bailey,Melisa L. Budde,Roger W. Wiseman,Richard A. Gibbs,Donna M. Muzny,Thomas C. Friedrich,Jeffrey Rogers,David H. O’Connor +19 more
TL;DR: This study establishes a framework for using whole genome sequencing to identify haplotypes that may contribute to complex clinical phenotypes and investigates the immunogenetics underlying spontaneous HIV control, suggesting that additional loci modify the major histocompatibility complex's protective effect.
Expansion of Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cell Lines from SIV-Naive Mauritian Cynomolgus Macaques for Adoptive Transfer
Mariel S. Mohns,Justin M. Greene,Brian T Cain,Ngoc H Pham,Emma Gostick,David Price,David H. O’Connor +6 more
TL;DR: The expansion and autologous transfer of Siv-specific T cells from SIV-naive Mauritian cynomolgus macaques into naive animals provide a unique model for exploring cellular immunity and the control of SIV infection and facilitate a systematic evaluation of therapeutic adoptive transfer strategies for eradication of the latent reservoir.
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Adoptive Transfer of Lymphocytes Isolated from Simian Immunodeficiency Virus SIVmac239Δnef-Vaccinated Macaques Does Not Affect Acute-Phase Viral Loads but May Reduce Chronic-Phase Viral Loads in Major Histocompatibility Complex-Matched Recipients
Justin M. Greene,Jennifer J. Lhost,Paul J. Hines,Matthew Scarlotta,Max Harris,Benjamin J. Burwitz,Melisa L. Budde,Dawn M. Dudley,Ngoc H Pham,Brian T Cain,Caitlin E. Mac Nair,Madelyn K. Weiker,Shelby L. O’Connor,Thomas C. Friedrich,David H. O’Connor +14 more
TL;DR: Results may suggest that adoptive transfers influenced the course of infection despite the lack of significant differences in the viral loads among animals that received cells from vaccinated and mock-vaccinated donor animals.
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T cell response specificity and magnitude against SIVmac239 are not concordant in major histocompatibility complex-matched animals
Brian T Cain,Ngoc H Pham,Melisa L. Budde,Justin M. Greene,Jason T. Weinfurter,Matthew Scarlotta,Max Harris,Emily N. Chin,Shelby L. O’Connor,Thomas C. Friedrich,David H. O’Connor +10 more
TL;DR: In this article, the authors used a genetically restricted population of Mauritian cynomolgus macaques (MCM) to characterize T cell responses within nine pairs of MHC-matched animals.