Nessy Tania
Smith College
12 Papers
57 Citations
Nessy Tania is an academic researcher from Smith College. The author has contributed to research in topics: Cofilin & Ryanodine receptor. The author has an hindex of 8, co-authored 12 publications. Previous affiliations of Nessy Tania include University of British Columbia & University of Utah.
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Papers
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High Throughput Screening Assays for the Estrogen Receptor
Richard S. Judson,F. M. G. Magpantay,Vijay Chickarmane,Cymra Haskell,Nessy Tania,Jean E. Taylor,Menghang Xia,Ruili Huang,Daniel M. Rotroff,Dayne L. Filer,Keith A. Houck,Matthew T. Martin,Nisha S. Sipes,Ann M. Richard,Kamel Mansouri,R. Woodrow Setzer,Thomas B. Knudsen,Kevin M. Crofton,Russell S. Thomas +18 more
TL;DR: A computational network model is demonstrated that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin binding, transcriptional activation, and ER-dependent cell proliferation and is generalizable to any molecular pathway for which there are multiple upstream and downstream assays available.
279
A Mathematical Model of Airway and Pulmonary Arteriole Smooth Muscle
TL;DR: It is predicted that oscillations in calcium concentration, commonly observed during agonist-induced smooth muscle contraction, cause a significantly greater contraction than an elevated steady calcium concentration and that murine airway SMCs exploit a Ca2+-dependent mechanism to favor a default state of relaxation.
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A Temporal Model of Cofilin Regulation and the Early Peak of Actin Barbed Ends in Invasive Tumor Cells
TL;DR: It is demonstrated that a high basal level of active cofilin stored by binding to PIP(2), as well as the highly enriched local milieu of F-actin at the cell edge, is essential to capture the EGF-induced barbed-end amplification observed experimentally.
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Modeling the Synergy of Cofilin and Arp2/3 in Lamellipodial Protrusive Activity
TL;DR: The model supports a direct role for cofilin-mediated actin polymerization in stimulated cell migration, including chemotaxis and cancer invasion, according to a range of activation rates.
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A Mathematical Model for Tumor–Immune Dynamics in Multiple Myeloma
Jill Gallaher,Kamila Larripa,Urszula Ledzewicz,Urszula Ledzewicz,Marissa Renardy,Marissa Renardy,Blerta Shtylla,Nessy Tania,Diana White,Karen E. Wood,Karen E. Wood,Li Zhu,Chaitali Passey,Michael Robbins,Natalie Bezman,Suresh Shelat,Hearn Jay Cho,Helen Moore,Helen Moore +18 more
- 01 Jan 2018
TL;DR: Analysis of the reduced two-dimensional model of the dynamics of multiple myeloma revealed details about long-term model behavior, and theoretical results describing equilibria and their associated stability are described in detail.
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