Nemanja Saric
National Institutes of Health
5 Papers
Nemanja Saric is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
TL;DR: The noncanonical, non-lethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied as discussed by the authors .
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Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model
Kamil Sarkislali,Kei Kobayashi,Nemanja Saric,Takuya Maeda,Soichiro Henmi,Fahad A. Somaa,Ankush Bansal,Shao Ching Tu,Camille Leonetti,Chao-Hsiung Hsu,Jingang Li,Pranav Vyas,Yuka Imamura Kawasawa,Tsang-Wei Tu,Paul C. Wang,Patrick J. Hanley,Kazue Hashimoto-Torii,Joseph A. Frank,Richard A. Jonas,Nobuyuki Ishibashi +19 more
TL;DR: Mesenchymal stromal cell delivery via cardiopulmonary bypass minimizes microglial activation and neuronal apoptosis, improving cortical dysmaturation and behavioral alterations in a juvenile porcine model of congenital heart disease, with potential translational benefits for children.
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Abstract 10858: Mesenchymal Stromal Cell Delivery via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Surgical Model
Kei Kobayashi,Kamil Sarkislali,Nemanja Saric,Takuya Maeda,Fahad A. Somaa,Mobolanle A Ayodeji,Camille Leonetti,Chao-Hsiung Hsu,Jingang Li,Pranav Vyas,Yuka Imamura Kawasawa,Tsang-Wei Tu,Patrick J. Hanley,Kazue Hashimoto-Torii,Joseph A. Frank,Richard A. Jonas,Nobuyuki Ishibashi +16 more
TL;DR: In this article , BM-MSC delivery via CPB minimizes inflammatory/oxidative stress and reduces neuronal caspase and microglial activation, with subsequent rescue of behavioral/structural impairments in children undergoing cardiac surgery.
Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease
Jennifer Romanowicz,Camille Leonetti,Zaenab Dhari,Ludmila Korotcova,Shruti D. Ramachandra,Nemanja Saric,Paul D. Morton,Shivani Bansal,Amrita K. Cheema,Vittorio Gallo,Richard A. Jonas,Nobuyuki Ishibashi +11 more
TL;DR: Repurposing BH4 for use during fetal brain development may limit white matter dysmaturation in congenital heart disease and mitigates the toxic effects of hypoxia on white matter.
The role of primary cilia in congenital heart defect-associated neurological impairments
Nemanja Saric,Nobuyuki Ishibashi +1 more
TL;DR: Congenital heart disease is linked to neurological impairments, with genetic variants affecting primary cilia integrity implicated in pathogenesis; review highlights current evidence and multifactorial nature of CHD, suggesting therapeutic targeting and patient stratification strategies.