Neil Chappell
Baylor College of Medicine
15 Papers
10 Citations
Neil Chappell is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Medicine & Polycystic ovary. The author has an hindex of 3, co-authored 11 publications. Previous affiliations of Neil Chappell include Boston Children's Hospital.
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Papers
Liraglutide 3 mg on weight, body composition, and hormonal and metabolic parameters in women with obesity and polycystic ovary syndrome: a randomized placebo-controlled-phase 3 study.
TL;DR: In this article , the efficacy and safety of the GLP-1 analog liraglutide 3 mg (LIRA 3 mg) vs. placebo (PL) for reduction of body weight and hyperandrogenism in women with obesity and polycystic ovary syndrome (PCOS).
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Exenatide, Dapagliflozin, or Phentermine/Topiramate Differentially Affect Metabolic Profiles in Polycystic Ovary Syndrome
TL;DR: In this paper, the efficacy of once-weekly exenatide (EQW) and dapagliflozin (DAPA) alone and coadministered with DAPA/extended-release (ER) metformin (DAPHA/MET), and phentermine topiramate extended release (PHEN/TPM) on metabolic parameters, body composition, and sex hormones were examined in obese women with PCOS.
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Prenatal androgen induced lean PCOS impairs mitochondria and mRNA profiles in oocytes
TL;DR: The lean PCOS mouse model shows a decreased oocyte quality related to impaired mitochondrial ultrastructure and function, which is similar to that of the controls but exhibit glucose intolerance and hyperinsulinemia along with dysregulated estrus cycle.
Hyperandrogenemia alters mitochondrial structure and function in the oocytes of obese mouse with polycystic ovary syndrome.
Neil Chappell,Beth Zhou,Pardis Hosseinzadeh,Amy K. Schutt,William E. Gibbons,Chellakkan S. Blesson +5 more
- 01 Feb 2021
TL;DR: The obese PCOS mouse model shows a decreased oocyte quality related to impaired mitochondrial function, which demonstrated impaired inner mitochondrial membrane function, increased ATP production and mtDNA copy number, altered RNA transcript abundance and aberrant ovarian histology.
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Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls.
Neil Chappell,Neil Chappell,Maya Barsky,Maya Barsky,Jaimin S. Shah,M. Peavey,M. Peavey,L. Yang,Haleh Sangi-Haghpeykar,William Gibbons,William Gibbons,Chellakkan S. Blesson,Chellakkan S. Blesson +12 more
- 01 Sep 2020
TL;DR: The alterations in early embryo development are consistent with altered fertility and obstetric outcomes in the population with PCOS and may be due to the hyperandrogenic microenvironment in the ovarian follicle.
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