Neha Malik
Northwestern University
9 Papers
30 Citations
Neha Malik is an academic researcher from Northwestern University. The author has contributed to research in topics: Glyceollin I & Retinoic acid receptor alpha. The author has an hindex of 4, co-authored 9 publications. Previous affiliations of Neha Malik include University of Toledo.
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Papers
Multigram Synthesis of Glyceollin I
Amarjit Luniwal,Rahul S. Khupse,Michael D. Reese,Jidong Liu,Mohammad H. El-Dakdouki,Neha Malik,Lei Fang,Paul W. Erhardt +7 more
TL;DR: In this paper, a cis-fused ring system was constructed after Sharpless asymmetric dihydroxylation of a key intermediate that was initially produced by an intramolecular Wittig reaction to afford the requisite alkene while simultaneously forming the first ring.
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Total Synthesis of (±)-Glyceollin II and a Dihydro Derivative.
TL;DR: This work constitutes the first total directed synthesis of (±)-glyceollin II, and involves 12 steps with an overall yield of 7% using practical methods that should be readily scalable to produce quantities needed for advanced biological characterization.
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Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound.
TL;DR: A modified synthesis of a known RARα antagonist and a synthesis of its unknown, desfluoro analog, 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl]carbonyl]amino]benzoic acid is reported, which allows for facile reaction workups, increased yields, lower cost and incorporates a green alternative step.
11
Synthesis of a novel fused pyrrolodiazepine-based library with anti-cancer activity.
TL;DR: Screening shows anti-cancer activity of several library compounds which suggests translational potential of this novel chemical scaffold.
10
Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands.
TL;DR: The development of a new class of tetrahydroindazoles that are highly potent and selective ligands for sigma-1 and will be useful in the development of new chemical probes for this protein and to aid in future work therapeutically targeting this protein.
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