Neelima Bhargava
University of Central Florida
15 Papers
185 Citations
Neelima Bhargava is an academic researcher from University of Central Florida. The author has contributed to research in topics: Skeletal muscle & Cell culture. The author has an hindex of 12, co-authored 15 publications.
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Papers
Auto-catalytic Ceria Nanoparticles Offer Neuroprotection to Adult Rat Spinal Cord Neurons
Mainak Das,Swanand Patil,Neelima Bhargava,Jung-Fong Kang,Lisa Riedel,Sudipta Seal,James J. Hickman +6 more
TL;DR: Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay and a mechanism is proposed to explain the auto-catalytic properties of these nanoparticles.
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A defined long-term in vitro tissue engineered model of neuromuscular junctions.
TL;DR: A serum-free culture system utilizing defined temporal growth factor application and a non-biological substrate resulted in the formation of robust NMJ formation, which will find applications in basic NMJ research and tissue engineering applications such as bio-hybrid device development for limb prosthesis and regenerative medicine.
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Embryonic motoneuron-skeletal muscle co-culture in a defined system.
Mainak Das,John W. Rumsey,Cassie Gregory,Neelima Bhargava,Jung Fong Kang,Jung Fong Kang,Peter Molnar,Peter Molnar,Lisa Riedel,Lisa Riedel,Xiufang Guo,James J. Hickman,James J. Hickman +12 more
TL;DR: A minimalist serum-free defined system to co-culture rat mammalian nerve and muscle cells in order to form functional neuromuscular junctions provides a basic system that can be utilized for nerve-muscle tissue engineering, regenerative medicine and development of limb prosthetics.
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A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology.
Kucku Varghese,Kucku Varghese,Peter Molnar,Mainak Das,Neelima Bhargava,Stephen Lambert,Mark S. Kindy,James J. Hickman,James J. Hickman +8 more
TL;DR: This work believes it has identified a new target for drug development for AD based on functional toxicity of hippocampal neurons that could treat neurodegenerative diseases prior to the development of mild cognitive impairment.
Skeletal muscle tissue engineering: a maturation model promoting long-term survival of myotubes, structural development of the excitation-contraction coupling apparatus and neonatal myosin heavy chain expression.
TL;DR: A defined model system for skeletal muscle maturation supports the goal of developing physiologically relevant muscle constructs for use in tissue engineering and regenerative medicine as well as for high-throughput screening applications.
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