Neal L. Benowitz
University of California, San Francisco
826 Papers
9K Citations
Neal L. Benowitz is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Nicotine & Cotinine. The author has an hindex of 126, co-authored 792 publications. Previous affiliations of Neal L. Benowitz include Shaare Zedek Medical Center & University College London.
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Papers
Benefit of hemoperfusion in acute theophylline intoxication
TL;DR: Evidence is provided that hemoperfusion or hemodialysis can reduce the duration of clinical intoxication and probably reduces mortality and morbidity in patients with severe theophylline intoxication.
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CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people.
Matthew J. Binnington,Andy Z. X. Zhu,Caroline C. Renner,Anne P. Lanier,Dorothy K. Hatsukami,Neal L. Benowitz,Rachel F. Tyndale +6 more
TL;DR: Yupik AN people have a unique CYP2A6 genetic profile that associated strongly with in-vivo nicotine metabolism and may modulate the risk of tobacco-related diseases.
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Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.
Andy Z. X. Zhu,Qian Zhou,Lisa Sanderson Cox,Jasjit S. Ahluwalia,Neal L. Benowitz,Rachel F. Tyndale +5 more
TL;DR: NMR is not altered by differences in the rate of 3HC glucuronidation, providing further support that NMR is a reliable indicator of CYP2A6 mediated nicotine metabolism and is unlikely to affect the clinical utility of NMR in smoking behavior and cessation studies.
Pharmacodynamics of nicotine: implications for rational treatment of nicotine addiction.
TL;DR: Pharmacodynamic considerations are discussed in relation to the elements of smoking cessation therapy: setting objectives, selecting appropriate medication and dosing form, selecting the optimal doses and dosage regimens, assessing therapeutic outcome, and adjusting therapy to optimize benefits and minimize risks.
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The variability of urinary cotinine levels in young children: implications for measuring ETS exposure.
Georg E. Matt,Melbourne F. Hovell,Penelope J.E. Quintana,Joy M. Zakarian,Sandy Liles,Susan B. Meltzer,Neal L. Benowitz +6 more
TL;DR: It is indicated that cotinine measures from single urine samples provided highly accurate estimates of only recent exposure, and up to 12 urine samples may be required to achieve similarly precise estimates of ETS exposure over a 4- to 13-month period.
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